ArticleBMC geriatrics2024
Age-related changes in sleep spindle characteristics in individuals over 75 years of age: a retrospective and comparative study.
Article in BMC geriatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults.Frontiers in aging neuroscience · 2026Article
- Ambient fine-particulate air pollution associates with short sleep duration among 2,082 community-dwelling older adults: findings from a large-scale questionnaire survey.Frontiers in public health · 2026Article
- Differences in sleep spindles and polysomnography in humans: a meta-analysis on the influence of age, sex, and cognitive ability.Frontiers in sleep · 2026Review
- Sleep in neurodegenerative diseases: A focus on melatonin, melanin-concentrating hormone and orexin.Journal of neuroendocrinology · 2025Review
- The association of the non-HDL-cholesterol to HDL-cholesterol ratio (NHHR) with obstructive sleep apnea among adults aged ≥ 40 years: results from NHANES 2015-2018.BMC public health · 2025Article
- Differential expression of spatiotemporal sleep spindle clusters in aging.Sleep advances : a journal of the Sleep Research Society · 2025Article
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4 authors.
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Abstract
backgroundSleep and its architecture are affected and changing through the whole lifespan. We know main modifications of the macro-architecture with a shorter sleep, occurring earlier and being more fragmented. We have been studying sleep micro-architecture through its pathological modification in sleep, psychiatric or neurocognitive disorders whereas we are still unable to say if the sleep micro-architecture of an old and very old person is rather normal, under physiological changes, or a concern for a future disorder to appear. We wanted to evaluate age-related changes in sleep spindle characteristics in individuals over 75 years of age compared with younger individuals.
methodsThis was an exploratory study based on retrospective and comparative laboratory-based polysomnography data registered in the normal care routine for people over 75 years of age compared to people aged 65-74 years. We were studying their sleep spindle characteristics (localization, density, frequency, amplitude, and duration) in the N2 and N3 sleep stages. ANOVA and ANCOVA using age, sex and OSA were applied.
resultsWe included 36 participants aged > 75 years and 57 participants aged between 65 and 74 years. An OSA diagnosis was most common in both groups. Older adults receive more medication to modify their sleep. Spindle localization becomes more central after 75 years of age. Changes in the other sleep spindle characteristics between the N2 and N3 sleep stages and between the slow and fast spindles were conformed to literature data, but age was a relevant modifier only for density and duration.
conclusionWe observed the same sleep spindle characteristics in both age groups except for localization. We built our study on a short sample, and participants were not free of all sleep disorders. We could establish normative values through further studies with larger samples of people without any sleep disorders to understand the modifications in normal aging and pathological conditions and to reveal the predictive biomarker function of sleep spindles.
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