Evidence map›Paper›PMID 39304772›Full record

ArticleNature cancer2024

Spatial analysis reveals targetable macrophage-mediated mechanisms of immune evasion in hepatocellular carcinoma minimal residual disease.

Lea Lemaitre, Nia Adeniji, Akanksha Suresh, Reshma Reguram, Josephine Zhang, Jangho Park, Amit Reddy, Alexandro E Trevino, Aaron T Mayer, Anja Deutzmann and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

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  11. [Heterogeneity of tumor-associated macrophages and precision targeting strategies in hepatocellular carcinoma].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Lea Lemaitre *Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1940-1018
Nia Adeniji *Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Akanksha Suresh *Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Reshma ReguramDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0003-5453-0082
Josephine ZhangDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Jangho ParkDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Amit ReddyDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0009-0001-4561-3180
Alexandro E TrevinoEnable Medicine, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0002-9763-1540
Aaron T MayerEnable Medicine, Menlo Park, CA, USA.ORCID http://orcid.org/0000-0001-6429-0420
Anja DeutzmannDivision of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-3271-1427
Aida S HansenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Ling TongDivision of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA, USA.
Vinodhini ArjunanDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA.
Neeraja KambhamDepartment of Pathology, Stanford University, Stanford, CA, USA.
Brendan C VisserDepartment of Surgery, Stanford University, Stanford, CA, USA.
Monica M DuaDepartment of Surgery, Stanford University, Stanford, CA, USA.
C Andrew BonhamDepartment of Surgery, Stanford University, Stanford, CA, USA.
Nishita KotharyDepartment of Radiology, Stanford University, Stanford, CA, USA.
H Blaize D'AngioEnable Medicine, Menlo Park, CA, USA.
Ryan PreskaEnable Medicine, Menlo Park, CA, USA.
Yanay RosenDepartment of Biomedical Data Science and Computer Science, Stanford University, Stanford, CA, USA.
James ZouDepartment of Biomedical Data Science and Computer Science, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8880-4764
Vivek CharuDepartment of Pathology, Stanford University, Stanford, CA, USA.
Dean W FelsherDivision of Oncology, Departments of Medicine and Pathology, Stanford University, Stanford, CA, USA. dfelsher@stanford.edu.ORCID http://orcid.org/0000-0003-2496-523X
Renumathy DhanasekaranDivision of Gastroenterology and Hepatology, Stanford University, Stanford, CA, USA. dhanaser@stanford.edu.ORCID http://orcid.org/0000-0001-8819-7511

Funding

Targeting the MYC Pathway for the Treatment of CancerR35CA253180 · NCI · STANFORD UNIVERSITY · PI DEAN W FELSHER · 2020 to 2026
$6.9M
(PQ7)Multi-scale Analysis of Tumor Microenvironment HeterogeneityR01CA208735 · NCI · STANFORD UNIVERSITY · PI FELSHER, DEAN W · 2017 to 2019
$2.2M
Functional Proteomic Analysis and Biomarker Identification in a Novel Mouse Model of Metastatic Hepatocellular Carcinoma (HCC)K08CA222676 · NCI · STANFORD UNIVERSITY · PI DHANASEKARAN, RENUMATHY · 2018 to 2022
$1.0M
Center for Strategic Scientific Initiatives, National Cancer Institute (NCI Center for Strategic Scientific Initiatives) CA208735Center for Strategic Scientific Initiatives, National Cancer Institute (NCI Center for Strategic Scientific Initiatives) CA253180NCI NIH HHS K08 CA222676NCI NIH HHS R01 CA208735NCI NIH HHS R35 CA253180
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) frequently recurs from minimal residual disease (MRD), which persists after therapy. Here, we identified mechanisms of persistence of residual tumor cells using post-chemoembolization human HCC (n = 108 patients, 1.07 million cells) and a transgenic mouse model of MRD. Through single-cell high-plex cytometric imaging, we identified a spatial neighborhood within which PD-L1 + M2-like macrophages interact with stem-like tumor cells, correlating with CD8

Indexed as

B7-H1 AntigenCarcinoma, HepatocellularLiver NeoplasmsMacrophagesMice, TransgenicNeoplasm, ResidualAnimalsCD8-Positive T-LymphocytesHumansImmune EvasionMiceNeoplastic Stem CellsSpatial AnalysisTransforming Growth Factor beta1Tumor EscapeTumor MicroenvironmentB7-H1 AntigenCD274 protein, humanTransforming Growth Factor beta1

Identifiers

PMID39304772
PMCPMC12258040

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.