Evidence map›Paper›PMID 39304538›Full record

ReviewMammalian genome : official journal of the International Mammalian Genome Society2024

The mutant mouse resource and research center (MMRRC) consortium: the US-based public mouse repository system.

Yuksel Agca, James Amos-Landgraf, Renee Araiza, Jennifer Brennan, Charisse Carlson, Dominic Ciavatta, Dave Clary, Craig Franklin, Ian Korf, Cathleen Lutz and 7 more

Abstract readReview
In one paragraph

Review in Mammalian genome : official journal of the International Mammalian Genome Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Cryopreservation of Rodent Ovarian Tissues and Oocytes.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yuksel AgcaDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
James Amos-LandgrafDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
Renee AraizaDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Jennifer BrennanDepartment of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Charisse CarlsonDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Dominic CiavattaDepartment of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Dave ClaryDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Craig FranklinDepartment of Veterinary Pathobiology, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA.
Ian KorfDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Cathleen LutzThe Jackson Laboratory, Bar Harbor, Maine, USA.
Terry MagnusonDepartment of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Fernando Pardo-Manuel de VillenaDepartment of Genetics and Lineberger Comprehensive Cancer Center, University of North Carolina-Chapel Hill, Chapel Hill, NC, USA.
Oleg MirochnitchenkoDivision of Comparative Medicine, Office of Research Infrastructure Programs, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, National Institutes of Health, Bethesda, USA.
Samit PatelDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Dan PortDepartment of Molecular and Cellular Biology, College of Biological Sciences and Bioinformatics Core, Genome Center, University of California, Davis, CA, USA.
Laura ReinholdtThe Jackson Laboratory, Bar Harbor, Maine, USA.
K C Kent LloydMouse Biology Program, University of California, Davis, CA, USA. kclloyd@ucdavis.edu.

Funding

KOMP2-Phase3 Production and Phenotyping by the DTCC Consortium TCP Transfer to UC DavisUM1OD023221 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2016 to 2026
$45.7M
UCD Mutant Mouse Regional Resource CenterU42OD012210 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$29.2M
The Mutant Mouse Resource and Research Center at the University of Missouri - ResourceU42OD010918 · OD · UNIVERSITY OF MISSOURI-COLUMBIA · PI James Amos-Landgraf · 2012 to 2026
$25.1M
Resource Section - Core 001U42OD010924 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TERRY R MAGNUSON · 2012 to 2026
$24.5M
The Mutant Mouse Resource and Research Center at The Jackson LaboratoryU42OD010921 · OD · JACKSON LABORATORY · PI Cathleen M Lutz · 2012 to 2026
$21.4M
MMRRC Informatics, Coordination, and Service Center at UC DavisU42OD010983 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KC KENT LLOYD · 2012 to 2026
$12.9M
NIH HHS U42 OD010918NIH HHS U42 OD010921NIH HHS U42 OD010924NIH HHS U42 OD010983NIH HHS U42 OD012210NIH HHS UM1 OD023221ORIP NIH HHS U42OD010918ORIP NIH HHS U42OD010921ORIP NIH HHS U42OD010924ORIP NIH HHS U42OD010983ORIP NIH HHS U42OD012210
6 · The paper itself

Abstract

Now in its 25th year, the Mutant Mouse Resource and Research Center (MMRRC) consortium continues to serve the United States and international biomedical scientific community as a public repository and distribution archive of laboratory mouse models of human disease for research. Supported by the National Institutes of Health (NIH), the MMRRC consists of 4 regionally distributed and dedicated vivaria, offices, and specialized laboratory facilities and an Informatics Coordination and Service Center (ICSC). The overarching purpose of the MMRRC is to facilitate groundbreaking biomedical research by offering an extensive repertoire of mutant mice that are essential for advancing the understanding of human physiology and disease. The function of the MMRRC is to identify, acquire, evaluate, characterize, cryopreserve, and distribute mutant mouse strains to qualified biomedical investigators around the nation and the globe. Mouse strains accepted from the research community are held to the highest scientific standards to optimize reproducibility and enhance scientific rigor and transparency. All submitted strains are thoroughly reviewed, documented, and validated using extensive scientific quality control measures. In addition, the MMRRC conducts resource-related research on cryopreservation, mouse genetics, environmental conditions, and other topics that enhance operations of the MMRRC. Today, the MMRRC maintains an archive of mice, cryopreserved embryos and sperm, embryonic stem (ES) cell lines, and murine hybridomas for nearly 65,000 alleles. Since its inception, the MMRRC has fulfilled more than 20,000 orders from 13,651 scientists at 8441 institutions worldwide. The MMRRC also provides numerous services to assist researchers, including scientific consultation, technical assistance, genetic assays, microbiome analysis, analytical phenotyping, pathology, cryorecovery, husbandry, breeding and colony management, infectious disease surveillance, and disease modeling. The ICSC coordinates MMRRC operations, interacts with researchers, and manages the website (mmrrc.org) and online catalogue. Researchers benefit from an expansive list of well-defined mouse models of disease that meet the highest scientific standards while submitting investigators benefit by having their mouse strains cryopreserved, protected, and distributed in compliance with NIH policies.

Indexed as

CryopreservationAnimalsBiomedical ResearchDisease Models, AnimalHumansMiceMice, Mutant StrainsNational Institutes of Health (U.S.)United StatesCryopreservationDisease modelGeneticsMousePhenotypingRepository

Identifiers

PMID39304538
PMCPMC11522152

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.