Evidence map›Paper›PMID 39304441›Full record

ArticleSurgery2025

Sarcopenia is associated with survival in patients awaiting kidney transplant.

Julia Wendland, Abhinav Seth, Patrick Ten Eyck, Jude Longo, Grace Binns, M Lee Sanders, Jodell L Hornickel, Melissa Swee, Roberto Kalil, Daniel A Katz

Abstract read
In one paragraph

Article in Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia WendlandTransplant Department, Veterans Affairs Medical Center, Iowa City, IA.
Abhinav SethDepartment of Surgery, Organ Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, IA.
Patrick Ten EyckInstitute for Clinical and Translational Science, University of Iowa, Iowa City, IA.
Jude LongoRadiology Department, Veterans Affairs Medical Center, Iowa City, IA.
Grace BinnsTransplant Department, Veterans Affairs Medical Center, Iowa City, IA.
M Lee SandersTransplant Department, Veterans Affairs Medical Center, Iowa City, IA; Division of Nephrology, Department of Medicine, Organ Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, IA.
Jodell L HornickelTransplant Department, Veterans Affairs Medical Center, Iowa City, IA.
Melissa SweeTransplant Department, Veterans Affairs Medical Center, Iowa City, IA; Division of Nephrology, Department of Medicine, Organ Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, IA.
Roberto KalilDepartment of Medicine, University of Maryland Medical Center and Veterans Affairs Medical Center, Baltimore, MD.
Daniel A KatzTransplant Department, Veterans Affairs Medical Center, Iowa City, IA; Department of Surgery, Organ Transplant Center, University of Iowa Hospitals and Clinics, Iowa City, IA. Electronic address: daniel-katz@uiowa.edu.

Funding

University of Iowa Institute for Clinical and Translational ScienceUM1TR004403 · NCATS · UNIVERSITY OF IOWA · PI Marlan R Hansen, Patricia Winokur · 2023 to 2026
$16.1M
CTSA K12 Program at The University of IowaK12TR004382 · NCATS · UNIVERSITY OF IOWA · PI ALEXANDER G BASSUK, Polly J Ferguson · 2023 to 2026
$3.0M
NCATS NIH HHS K12 TR004382NCATS NIH HHS UM1 TR004403
6 · The paper itself

Abstract

backgroundThe relationship of sarcopenia to frailty and other survival determinants in patients waitlisted for kidney transplant is not well characterized. Our goal was to evaluate the relationship of muscle area to functional and frailty metrics and its impact on survival in patients waitlisted for kidney transplant.

methodsAmong 303 consecutively listed transplant candidates, 172 had a computed scan within 3 months of frailty and biochemical testing that permitted muscle area evaluation. Third lumbar level psoas muscle indices (total bilateral psoas area/height

resultsDemographic factors associated with third lumbar level psoas muscle indices include male sex (P < .001), race (P = .02), age (P = .004), and body mass index (P < .0001). Grip strength, treadmill ability, and Sit-Stands positively correlated with third lumbar level psoas muscle indices (P < .01). Brain natriuretic peptide and Up and Go negatively correlated with third lumbar level psoas muscle indices (P < .01). Survival was significantly associated with third lumbar level psoas muscle indices (P = 0.02). Treadmill ability, Sit-Stands, Up and Go, race and muscle area were most closely associated with waitlist survival on multivariate modeling.

conclusionSarcopenia as assessed with muscle area measurements is independently associated with kidney waitlist survival. Functional ability and muscle area may be overlapping, but noncongruent, determinants of waitlist outcomes and may need to be individually assessed to create the most predictive survival model.

Indexed as

FrailtyKidney Failure, ChronicKidney TransplantationSarcopeniaWaiting ListsAdultAgedFemaleHumansMaleMiddle AgedProportional Hazards ModelsPsoas Muscles

Identifiers

PMID39304441
PMCPMC11786994

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.