ArticleArchives of disease in childhood. Fetal and neonatal edition2025
Neonatal hyperinsulinism: a retrospective study of presentation and management in a tertiary neonatal intensive care unit in the UK.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Hyperinsulinemia After Extensive Small Bowel Resection and Total Parenteral Nutrition in a Neonate: A Case Study.Nutrition and metabolic insights · 2026Article
- Glycometabolic profiles and pregnancy outcomes across pathophysiological subtypes of gestational diabetes mellitus.Frontiers in endocrinology · 2026Article
- Continuous Glucose Monitoring in the Management of Congenital Hyperinsulinism: A National User-satisfaction Survey, UK.The Journal of clinical endocrinology and metabolism · 2025Article
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Authors and funding
4 authors.
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Abstract
objectiveReports of hyperinsulinism typically focus on infants managed by highly specialised services. However, neonates with hyperinsulinism are initially managed by neonatologists and often not referred to specialists. This study aimed to characterise the diversity in presentation and management of these infants.
settingLevel 3 neonatal intensive care. PATIENTS: Neonates with hyperinsulinism, defined as blood glucose <2.8 mmol/mL and insulin level >6 pmol/L.
design7-year retrospective study (January 2015-December 2021).
results99 cases were identified:
conclusionsThis study highlights the diversity in clinical presentation, severity and prognosis of neonatal hyperinsulinism, irrespective of birth weight and gestational age. More infants were small rather than large for gestational age, and the majority had transient hyperinsulinism and were not referred to the national centre, or treated with diazoxide. Further research is required to understand the breadth of neonatal hyperinsulinism and optimal management.
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