Evidence map›Paper›PMID 39303704›Full record

ArticleNeuron2024

An amygdalar oscillator coordinates cellular and behavioral rhythms.

Qiang Liu, Jiali Xiong, Dong Won Kim, Sang Soo Lee, Benjamin J Bell, Chloe Alexandre, Seth Blackshaw, Alban Latremoliere, Mark N Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. A Subcircuit in the Suprachiasmatic Nucleus Generates Wakefulness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. mWAKE in the Central Amygdala Regulates Fear Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  7. Article
  8. Article
  9. Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qiang LiuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Jiali XiongBiochemistry, Cellular and Molecular Biology Graduate Program, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Dong Won KimSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Sang Soo LeeDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Benjamin J BellDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Chloe AlexandreSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Seth BlackshawDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Alban LatremoliereSolomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Mark N WuDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: marknwu@jhmi.edu.

Funding

Cross-Species Analyses of the Molecular and Circuit Basis ofSleepR35NS122181 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Mark N Wu · 2021 to 2026
$6.9M
Development and function of hypothalamic Lhx6-positive neuronsR01MH126676 · NIMH · JOHNS HOPKINS UNIVERSITY · PI BLACKSHAW, SETH · 2021 to 2025
$2.0M
Sleep fragmentation by brief awakenings as a surrogate to measure neuropathic spontaneous painR01NS112266 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LATREMOLIERE, ALBAN A · 2020 to 2024
$1.9M
NIMH NIH HHS R01 MH126676NINDS NIH HHS R01 NS112266NINDS NIH HHS R35 NS122181
6 · The paper itself

Abstract

Circadian rhythms are generated by the master pacemaker suprachiasmatic nucleus (SCN) in concert with local clocks throughout the body. Although many brain regions exhibit cycling clock gene expression, the identity of a discrete extra-SCN brain oscillator that produces rhythmic behavior has remained elusive. Here, we show that an extra-SCN oscillator in the lateral amygdala (LA) is defined by expression of the clock-output molecule mWAKE/ANKFN1. mWAKE is enriched in the anterior/dorsal LA (adLA), and, strikingly, selective disruption of clock function or excitatory signaling in adLA

Indexed as

Circadian RhythmNeuronsPeriod Circadian ProteinsAmygdalaAnimalsBasolateral Nuclear ComplexBehavior, AnimalBiological ClocksMaleMiceMice, Inbred C57BLMice, TransgenicSuprachiasmatic NucleusPer2 protein, mousePeriod Circadian Proteinsanxietycircadianclocklateral amygdalalocal clockmWAKErhythmSCNtouch

Identifiers

PMID39303704
PMCPMC11581920

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.