ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024
Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Nanoparticle-Hydrogel Composites for Precision Medicine.Cell biomaterials · 2026Article
- Carbon Dot-Linked Hydrogel-Composite Scaffold with Sequential Release of Multi-Drug for Bone Repair.Gels (Basel, Switzerland) · 2026Article
- Encapsulation of carbon dots in medicinal chemistry: a comprehensive review of recent advances and applications.RSC advances · 2026Review
- Carbon Dot-Based Mechanofluorescent Hydrogel with Tunable Fluorescence for Bioengineering Applications.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Cell membranes-encapsulated gadolinium-doped carbon dots for the efficient photothermal and immunotherapeutic synergistic treatment of hepatocellular carcinoma.Journal of nanobiotechnology · 2026Article
- All-natural medicine food homology herb-based self-gelling hemostatic powder for rapid hemostasis and diabetic wound management.Journal of nanobiotechnology · 2026Article
- The Role of Carbon Dots in Regulating the Periodontal Immune Microenvironment: Progress and Perspectives.International journal of molecular sciences · 2025Review
- From Nutrition to Innovation: Biomedical Applications of Egg Components.Molecules (Basel, Switzerland) · 2025Review
- Carbon Dot-Linked Hydrogel for TAMs Transform: Spatiotemporal Manipulation to Reshape Tumor Microenvironment.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Porous Hydrogels Prepared by Two-Step Gelation Method for Bone Regeneration.Journal of functional biomaterials · 2025Article
- Facile preparation of fluorescent carbon dots from water caltrop shells and their application in amikacin sensing.RSC advances · 2025Article
- Food-Derived Tripeptide-Copper Self-Healing Hydrogel for Infected Wound Healing.Biomaterials research · 2025Article
- Carbon Dots Crosslinked Egg White Hydrogel for Tissue Engineering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
Egg white (EW)-derived hydrogels hold promise as biomaterials for in vitro cell culture due to their ability to mimic the extracellular matrix. However, their highly cross-linked structures restrict their potential for in vivo applications, as they are unable to integrate dynamically with tissues before degradation. In this study, this limitation is addressed by introducing carbon dots (CDs) as cross-linking agents for EW in a dilute aqueous solution. The resulting CDs-crosslinked EW hydrogel (CEWH) exhibits tensile strength comparable to that of skin tissue and features a large pore structure that promotes cell infiltration. Subcutaneous implantation of CEWH demonstrated excellent integration with surrounding tissue and a degradation rate aligned with the hair follicles (HFs) regeneration cycle. This allows the long-term regeneration and establishment of an M2 macrophage-dominated immune microenvironment, which in turn promotes the re-entry of HFs into the anagen phase from the telogen phase. Additionally, CEWH demonstrated potential as a wound dressing material. Overall, this study paves the way for utilizing EW as a versatile biomaterial for tissue engineering.
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Registered trials
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