Evidence map›Paper›PMID 39303132›Full record

Observational studyThe journal of extra-corporeal technology2024

Increased white blood cell count is associated with an increased demand for unfractionated heparin during veno-arterial extracorporeal oxygenation in lung transplantation.

Koichi Kashiwa, Hideo Kurosawa, Kazuki Fujishiro, Hitoshi Kubo, Ryota Inokuchi, Masahiko Bougaki, Gaku Kawamura, Masaaki Sato, Chihiro Konoeda, Jun Nakajima and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The journal of extra-corporeal technology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Koichi KashiwaDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Hideo KurosawaDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Kazuki FujishiroDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Hitoshi KuboDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Ryota InokuchiDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Masahiko BougakiDepartment of Anesthesiology, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Gaku KawamuraDepartment of Anesthesiology, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Chihiro KonoedaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Jun NakajimaDepartment of Thoracic Surgery, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.
Kent DoiDepartment of Clinical Engineering, The University of Tokyo Hospital, 7-3-1, Hongo, Bunkyo-city, Tokyo 113-8655, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis retrospective observational study aimed to examine whether clinical inflammatory parameters were associated with the requirement dosage of unfractionated heparin (UFH) to maintain the range of ACT in veno-arterial extracorporeal membrane oxygenation (V-A ECMO) during lung transplantation surgery.

methodsAmong all patients who underwent lung transplantation using V-A ECMO from January 2021 to May 2022, 27 patients were included. These patients were divided into two groups based on whether the infusion rate of UFH was increased from the initial infusion rate (7-8 units/kg/h) (increased group, n = 10) or the infusion rate was maintained or decreased (non-increased group, n = 17). The infusion rate was adjusted with an activated clotting time (ACT) target of 160-200 s.

resultsAt 1-2 h after starting ECMO, ACT was significantly lower (179.0 (166.5-188.5) versus 224.0 (193.0-242.0) sec, p = 0.006) and white blood cell (WBC) counts were higher in the increased group (12.6 ± 3.3 versus 9.5 ± 4.0 × 10

conclusionThese data suggested that WBC count was associated with the requirement of an increase in the UFH infusion rate of V-A ECMO during lung transplantation surgery. Further evaluation is necessary to clarify the role of WBC count in determining the optimal UFH dosage.

Indexed as

Extracorporeal Membrane OxygenationHeparinLung TransplantationAdultAnticoagulantsFemaleHumansLeukocyte CountMaleMiddle AgedRetrospective StudiesAnticoagulantsHeparinLung transplantationUnfractionated heparinVeno-arterial extracorporeal membrane oxygenationWhite blood cell

Identifiers

PMID39303132
PMCPMC11415038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.