Evidence map›Paper›PMID 39303044›Full record

ReviewScience advances2024

Short-term plasticity and context-dependent circuit function: Insights from retinal circuitry.

Zixuan Deng, Swen Oosterboer, Wei Wei

Abstract readReview
In one paragraph

Review in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Co-Evaporated Ratio-Tunable TeSmall (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  3. Article
  4. Article
  5. Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Review
  6. Review
  7. Article
  8. Retinal Neurochemistry.Brain sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Zixuan DengThe Committee on Neurobiology Graduate Program, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-6524-6771
Swen OosterboerThe Committee on Neurobiology Graduate Program, The University of Chicago, Chicago, IL 60637, USA.ORCID 0009-0007-5143-8538
Wei WeiDepartment of Neurobiology and the Neuroscience Institute, The University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-7771-5974

Funding

Dynamic interactions between synaptic and intrinsic properties of starburst amacrine cells for robust motion detectionR01EY035268 · NEI · UNIVERSITY OF CHICAGO · PI Wei Wei · 2024 to 2026
$1.6M
Training in Theory and Computation for Next Generation NeuroscientistsR90DA060338 · NIDA · UNIVERSITY OF CHICAGO · PI Brent D. Doiron, Jason Neil MacLean · 2023 to 2026
$989k
NEI NIH HHS R01 EY035268NIDA NIH HHS R90 DA060338
6 · The paper itself

Abstract

Changes in synaptic strength across timescales are integral to algorithmic operations of neural circuits. However, pinpointing synaptic loci that undergo plasticity in intact brain circuits and delineating contributions of synaptic plasticity to circuit function remain challenging. The whole-mount retina preparation provides an accessible platform for measuring plasticity at specific synapses while monitoring circuit-level behaviors during visual processing ex vivo. In this review, we discuss insights gained from retina studies into the versatile roles of short-term synaptic plasticity in context-dependent circuit functions. Plasticity at single synapse level greatly expands the algorithms of common microcircuit motifs and contributes to diverse circuit-level behaviors such as gain modulation, selective gating, and stimulus-dependent excitatory/inhibitory balance. Examples in retinal circuitry offer unequivocal support that synaptic plasticity increases the computational capacity of hardwired neural circuitry.

Indexed as

Neuronal PlasticityRetinaSynapsesAnimalsHumansNerve Net

Identifiers

PMID39303044
PMCPMC11414732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.