Evidence map›Paper›PMID 39303038›Full record

ArticleScience advances2024

Cancer-associated SF3B1-K700E mutation controls immune responses by regulating T

Yun Shi, Wencan Zhang, Qiong Jia, Xiancai Zhong, Prajish Iyer, Hongmin Wu, Yate-Ching Yuan, Yuqi Zhao, Lianjun Zhang, Lili Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Splicing-driven post-translational dysregulation: a new frontier for precision cancer medicine and immunotherapy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yun ShiDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4114-3388
Wencan ZhangDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-8828-2000
Qiong JiaDepartment of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA.ORCID 0000-0002-3063-2346
Xiancai ZhongDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-8312-4057
Prajish IyerDepartment of System Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-6982-6343
Hongmin WuDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-0762-8322
Yate-Ching YuanTranslational Bioinformatics, Department of Computational Quantitative Medicine, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-3698-9784
Yuqi ZhaoIntegrated Genomics Core, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4256-4512
Lianjun ZhangGehr Family Center for Leukemia Research, Department of Hematological Malignancies Translational Science, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.
Lili WangDepartment of System Biology, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-5028-2868
Zhenyu JiaDepartment of Botany & Plant Sciences, University of California, Riverside, CA 92527, USA.ORCID 0000-0002-1428-904X
Ya-Huei KuoGehr Family Center for Leukemia Research, Department of Hematological Malignancies Translational Science, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-2595-0419
Zuoming SunDepartment of Immunology & Theranostics, Arthur Riggs Diabetes & Metabolism Research Institute, Beckman Research Institute of the City of Hope, Duarte, CA 91010, USA.ORCID 0000-0003-1896-6666

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Steroid nuclear receptor coactivators in T cell differentiationR01AI109644 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI Zuoming Sun · 2014 to 2026
$6.9M
Function of TCF-1 in antagonizing malignancyR21AI163256 · NIAID · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI SUN, ZUOMING · 2021 to 2022
$484k
NCI NIH HHS P30 CA033572NIAID NIH HHS R01 AI109644NIAID NIH HHS R21 AI163256
6 · The paper itself

Abstract

Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic malignancies, with SF3B1-K700E being the most common one. Here, we show that regulatory T cell (T

Indexed as

MutationRNA Splicing FactorsT-Lymphocytes, RegulatoryAnimalsCell DifferentiationColitisHumansMiceNeoplasmsPhosphoproteinsRNA SplicingPhosphoproteinsRNA Splicing FactorsSf3b1 protein, mouse

Identifiers

PMID39303038
PMCPMC11414738

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.