ArticleScience immunology2024
Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation.
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Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
–field-weighted citation impact
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Who cites it
27 citing papers in PubMed.
- Uridine and pyruvate supplementation is associated with Th1 polarization during mitotoxic antibiotic therapy.iScience · 2026Article
- Metabolic exhaustion and immune ageing in rheumatoid arthritis.Nature reviews. Rheumatology · 2026Review
- Risk factors analysis of poor prognosis in ICU-admitted children with severe influenza pneumonia: a retrospective case-control study.Italian journal of pediatrics · 2026Article
- Preexisting IgG forms immune complexes and links local thermal reactogenicity with immunogenicity in influenza vaccination.NPJ vaccines · 2026Article
- Th17 cells require the DNA repair sensor xeroderma pigmentosum complementation Group C to control oxidative DNA damage in a murine model.Nature communications · 2026Article
- Immune responses of Bos indicus versus Bos taurus cattle towards Bluetongue virus or Schmallenberg virus differ significantly.Communications biology · 2026Article
- Automated Intracellular Immunofluorescence Staining Enabled by Magnetic 3D Mixing in a Modular Microfluidic Platform.Biosensors · 2026Article
- TRPM8 Regulates Mitochondrial CaJournal of cellular and molecular medicine · 2026Article
- Glutamine synthetase deficiency enhances CD8 T cell survival and stress resilience in the tumor microenvironment.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Febrile temperature activates the innate immune response by promoting aberrant influenza A virus RNA synthesis.Science advances · 2026Article
- Mitochondrial Energy Metabolism in Cancer, Immunoregulation and Antitumour Response.Advances in experimental medicine and biology · 2026Review
- Redox-metabolic circuits as a central regulator of T cell-based immunotherapy.Frontiers in immunology · 2026Review
- Rumen-host crosstalk: an amplifier of systemic pathology in heat-stressed ruminants.Frontiers in microbiology · 2026Review
- Pathway thermodynamic analysis postulates change in glutamate metabolism as a key factor in modulating immune responses.Immunometabolism (Cobham, Surrey) · 2026Article
- Fever Inspiration: Precision Engineering for Safe and Systemic Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Soluble IL-2 receptor and memory Treg profiles differentiate early rheumatoid arthritis from undifferentiated arthritis at initial presentation.Frontiers in immunology · 2026Article
- Nanomaterial-Based Photothermal Therapy for Inflammatory Diseases: Intervention Strategies, Synergistic Effects, and Future Challenges.International journal of nanomedicine · 2026Review
- Fructose intake driven glycolysis-ROS-EGFR axis specifically promotes the generation and pathogenicity of Th17 cells.Nature communications · 2025Article
- Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs).Journal of translational medicine · 2025Review
- Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025Article
Corrections and comments
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Authors and funding
29 authors.
Darren R HeintzmanDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4903-758X
Rachael C SinardDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-8282-8869
Emilie L FisherDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-9186-7512
Xiang YeDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-8694-8710
Andrew R PattersonDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-5177-5055
Joel H ElasyDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0002-5388-5810
Kelsey VossDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1732-2682
Channing ChiDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4987-4764
Ayaka SugiuraDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5326-5019
Gabriel J Rodriguez-GarciaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-4143-8669
Nowrin U ChowdhuryDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4621-1423
Emily N ArnerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-3589-8829
Evan S KrystoviakDepartment of Cell and Developmental Biology, Vanderbilt University, Nashville, TN, USA.
Frank M MasonDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1338-494X
Yasmine T ToudjiDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
KayLee K SteinerDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-2188-6376
Wasay KhanDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0006-8897-9322
Lana M OlsonVanderbilt Technologies for Advanced Genomics (VANTAGE), Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1315-380X
Angela L JonesVanderbilt Technologies for Advanced Genomics (VANTAGE), Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-1565-4360
Hanna S HongDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1202-2808
Lindsay BassDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Katherine L BeierDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Wentao DengDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0009-0004-9903-9702
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9309-6141
Dawn C NewcombDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Alexander G BickDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0001-5824-9595
W Kimryn RathmellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4984-0225
John T WilsonDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-9144-2634
Jeffrey C RathmellDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0002-4106-3396
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Ben Ho Park · 1995 to 2026
$172.8MTranslational Analysis CoreP30DK058404 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MARY Kay WASHINGTON · 2002 to 2026
$29.9MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI OWEN P MCGUINNESS · 2012 to 2026
$29.3MShop Module CoreP30EY008126 · NEI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David J. Calkins · 1989 to 2026
$19.6MEnhancing Treg Therapeutic Efficacy in GVHDR01HL118979 · NHLBI · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, HIPPEN, KELI L · 2014 to 2025
$6.7MVanderbilt Mouse Metabolic Phenotyping CenterU2CDK059637 · NIDDK · VANDERBILT UNIVERSITY · PI WASSERMAN, DAVID H · 2016 to 2021
$6.3MAutoimmune Drivers and Protectors Team Science (ADAPTS)U01AI176244 · NIAID · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JUDITH A JAMES, Jeffrey C Rathmell · 2023 to 2026
$5.1MExploiting metabolic vulnerabilities of CD4 T cell subsets to control inflammatory diseaseR01DK105550 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2015 to 2026
$4.7MInterdisciplinary Training in Rheumatic DiseasesT32AR059039 · NIAMS · VANDERBILT UNIVERSITY · PI Tracy Minan Frech, AMY S MAJOR · 2010 to 2026
$4.3MMetabolic Barriers to T Cell Activation in Clear Cell Renal Cell CarcinomaR01CA217987 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey C Rathmell · 2018 to 2026
$4.3MTargeting TH17 cell metabolism in steroid resistanceR01HL136664 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NEWCOMB, DAWN C, RATHMELL, JEFFREY C. · 2017 to 2024
$4.2MChemical Biology of Infectious Diseases (CBID) Training ProgramT32AI112541 · NIAID · VANDERBILT UNIVERSITY · PI Eric P Skaar · 2015 to 2026
$4.0MNCI NIH HHS K00 CA253718NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA217987NCI NIH HHS R01 CA245134NCI NIH HHS R01 CA266767NEI NIH HHS P30 EY008126NHLBI NIH HHS R01 HL118979NHLBI NIH HHS R01 HL136664NIAID NIH HHS R01 AI153167NIAID NIH HHS T32 AI112541NIAID NIH HHS U01 AI176244NIAMS NIH HHS T32 AR059039NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK058404NIDDK NIH HHS R01 DK105550NIDDK NIH HHS T32 DK101003NIDDK NIH HHS U2C DK059637
Abstract
Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased murine CD4 T cell metabolism, proliferation, and inflammatory effector activity while decreasing regulatory T cell suppressive capacity. However, heat-exposed T helper 1 (T
Indexed as
DNA DamageFeverInflammationMitochondriaAnimalsFemaleHumansMaleMiceMice, Inbred C57BLTh1 Cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.