Evidence map›Paper›PMID 39302996›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy.

Alexandra C Schwartz, Richard A Stein, Eva Gil-Iturbe, Matthias Quick, Hassane S Mchaourab

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The Nanodisc System for Investigating Protein-Lipid Interactions.Methods in molecular biology (Clifton, N.J.) · 2026
    Review
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alexandra C SchwartzChemical and Physical Biology Program, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-7846-3772
Richard A SteinDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.ORCID 0000-0002-0541-7150
Eva Gil-IturbeDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0002-4046-5756
Matthias QuickDepartment of Psychiatry, Columbia University Irving Medical Center, New York, NY 10032.ORCID 0000-0002-8620-827X
Hassane S MchaourabDepartment of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232.

Funding

MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Structure and Function of Neurotransmitter TransportersR01MH070039 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 2004 to 2024
$4.1M
Functional Dynamics of Neurotransmitter:Sodium Symporters (NSSs)R01MH134473 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hassane S Mchaourab, Matthias Quick · 2024 to 2026
$1.9M
Structural Dynamics of the Human Serotonin TransporterF31NS125911 · NINDS · VANDERBILT UNIVERSITY · PI SCHWARTZ, ALEXANDRA CORINNE · 2022 to 2024
$95k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) T32GM008320HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) F31NS125911NIGMS NIH HHS T32 GM008320NIMH NIH HHS R01 MH134473NINDS NIH HHS F31 NS125911
6 · The paper itself

Abstract

Neurotransmitter:sodium symporters (NSSs) play critical roles in neural signaling by regulating neurotransmitter uptake into cells powered by sodium electrochemical gradients. Bacterial NSSs orthologs, including MhsT from

Indexed as

Bacterial ProteinsBacillusElectron Spin Resonance SpectroscopyModels, MolecularNeurotransmitter AgentsProtein ConformationSodiumBacterial ProteinsNeurotransmitter AgentsSodiumAlphaFold2DEERneurotransmitter transportNSStransport mechanism

Identifiers

PMID39302996
PMCPMC11459141

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.