Evidence map›Paper›PMID 39302688›Full record

ArticleACS synthetic biology2024

A Massively Parallel

Courtney K Carlson, Theresa B Loveless, Marija Milisavljevic, Patrick I Kelly, Jeremy H Mills, Keith E J Tyo, Chang C Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Engineering a Virus-Derived X Family DNA Polymerase FvPolX for de novo DNA Synthesis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Courtney K CarlsonDepartment of Biomedical Engineering, University of California, Irvine, California 92697, United States.ORCID 0000-0003-4953-3222
Theresa B LovelessDepartment of Biomedical Engineering, University of California, Irvine, California 92697, United States.
Marija MilisavljevicDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0009-0000-7212-5513
Patrick I KellyCenter for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, Arizona 82587, United States.ORCID 0000-0002-7022-8209
Jeremy H MillsCenter for Molecular Design and Biomimetics, The Biodesign Institute, Arizona State University, Tempe, Arizona 82587, United States.ORCID 0000-0003-2017-1846
Keith E J TyoDepartment of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-2342-0687
Chang C LiuDepartment of Biomedical Engineering, University of California, Irvine, California 92697, United States.ORCID 0000-0002-3290-2880

Funding

Synthetic genetic systems for rapid biomolecular evolution in vivoR35GM136297 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI LIU, CHANG C · 2020 to 2024
$2.4M
NIGMS NIH HHS R35 GM136297
6 · The paper itself

Abstract

Terminal deoxynucleotidyl transferase (TdT) is a unique DNA polymerase capable of template-independent extension of DNA. TdT's

Indexed as

CRISPR-Cas SystemsDNA NucleotidylexotransferaseDNAHEK293 CellsHumansMutagenesis, InsertionalMutationNucleotidesRNA, Guide, CRISPR-Cas SystemsDNADNA NucleotidylexotransferaseNucleotidesRNA, Guide, CRISPR-Cas Systemsmolecular recordingpolymerase engineeringpooled screeningTdTterminal deoxynucleotidyl transferase

Identifiers

PMID39302688
PMCPMC11747941

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.