Evidence map›Paper›PMID 39302569›Full record

ReviewCurrent osteoporosis reports2024

Air Pollution and Osteoporosis.

Olivia Allen, Martin M Knight, Stefaan W Verbruggen

Abstract readReview
In one paragraph

Review in Current osteoporosis reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Airborne contaminant exposure and bone development: a systematic review and meta-analysis.Toxicological sciences : an official journal of the Society of Toxicology · 2026
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Olivia AllenCentre for Predictive in vitro Models, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-0866-4429
Martin M KnightCentre for Predictive in vitro Models, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0003-3755-1597
Stefaan W VerbruggenCentre for Predictive in vitro Models, Queen Mary University of London, London, UK. s.verbruggen@qmul.ac.uk.ORCID http://orcid.org/0000-0002-2321-1367

Funding

Engineering and Physical Sciences Research Council EP/Y001842/1NIHR Barts Biomedical Research Centre, Queen Mary University of London NIHR203330
6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to provide a background of osteoporosis and air pollution, discussing increasing incidence of the disease with exposure to pollutants and the role that inflammation may play in this process. RECENT

findingsOsteoporosis-related fractures are one of the most pressing challenges for the ageing global population, with significant increases in mortality known to occur after major osteoporotic fractures in the elderly population. Recent studies have established a firm correlative link between areas of high air pollution and increased risk of osteoporosis, particularly alarming given the increasingly urban global population. While the culprit pollutants and molecular mechanisms underlying this phenomenon have not yet been elucidated, initial studies suggest a role for inflammatory cascades in this phenomenon. While much more research is required to identify the most damaging air pollutants and to delineate the specific inflammatory molecular mechanisms, it is clear from the literature that shedding light on these pathways would unveil potential therapeutic targets to treat bone diseases, including osteoporosis. Major deficiencies of current animal models highlight the need for complex human in vitro models such as organ-on-a-chip technology to better understand the impact of air pollution.

Indexed as

Air PollutantsAir PollutionOsteoporosisAnimalsEnvironmental ExposureHumansInflammationOsteoporotic FracturesParticulate MatterAir PollutantsParticulate MatterAir pollutionBone mineral densityInflammationOsteoporosis

Identifiers

PMID39302569
PMCPMC11499323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.