Evidence map›Paper›PMID 39302517›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2024

Metabolic Changes in Myocardium and Skeletal Muscles of C57BL/6 Mice after Noncardiac Surgery.

M V Kondashevskaya, V V Aleksankina, K A Artemyeva, K A Kasabov, L V Kaktursky

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

M V KondashevskayaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia. marivladiko@mail.ru.
V V AleksankinaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
K A ArtemyevaAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
K A KasabovAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.
L V KakturskyAvtsyn Institute of Human Morphology, Petrovsky National Research Center of Surgery, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 10% of patients without cardiovascular disorders suffer myocardial injury and have a 10% risk of death within 30 days after noncardiac surgery. Preoperative stress increases the risk of myocardial injury after noncardiac surgery (MINS). The mechanisms of MINS are poorly understood. Lack of physical activity and the development of weakness and fatigue are consequences of many noncardiac surgery types. The relationship between surgery and changes in the morphofunctional state of muscles in the postoperative period is still unclear now. The study showed for the first time that metabolic and hormonal changes caused by preoperative stress + surgery or surgery alone underlie MINC in the postoperative period in C57BL/6 mice. Minor increases in triglyceride-glucose (TyG) index were for the first time identified as indicative of ischemic/hypoxic damage to the myocardium and skeletal muscles. More research is necessary to perform to better understand the effects of preoperative stress and noncardiac surgery on the myocardium and muscle performance, as well as the risks and benefits of perioperative treatment.

Indexed as

Muscle, SkeletalMyocardiumSurgical Procedures, OperativeAnimalsMaleMiceMice, Inbred C57BLTriglyceridesTriglyceridesanesthesiaC57BL/6 micemetabolic and hormonal changesmyocardial and skeletal muscle ischemiasurgery

Identifiers

PMID39302517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.