Evidence map›Paper›PMID 39301964›Full record

ReviewAmerican journal of physiology. Gastrointestinal and liver physiology2024

Fecal microbial transplants as investigative tools in cancer.

Margaret S Bohm, Arvind V Ramesh, Joseph F Pierre, Katherine L Cook, E Angela Murphy, Liza Makowski

Abstract readReview
In one paragraph

Review in American journal of physiology. Gastrointestinal and liver physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Murine Models of Obesity-Related Cancer Risk.Cancer prevention research (Philadelphia, Pa.) · 2025
    Review
  5. Article
  6. Therapeutic potential of microbiome modulation in reproductive cancers.Medical oncology (Northwood, London, England) · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Margaret S BohmDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0001-7409-7798
Arvind V RameshDivision of Hematology and Oncology, Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.
Joseph F PierreDepartment of Nutritional Sciences, College of Agriculture and Life Science, The University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-4248-1290
Katherine L CookDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, United States.ORCID 0000-0001-6241-0214
E Angela MurphyDepartment of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, United States.ORCID 0000-0002-4803-5822
Liza MakowskiDepartment of Microbiology, Immunology, and Biochemistry, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, United States.ORCID 0000-0002-5337-8037

Funding

Determining the contribution of microbial-derived metabolites to protective immunity in obesity-driven cancer risk.U01CA272541 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Liza Makowski-Hayes, Joseph F PIERRE · 2022 to 2026
$5.1M
A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer - admin supplementU01CA272977 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JAMES R HEBERT, Lorne J Hofseth · 2022 to 2026
$4.7M
Role of microbial-modulated bile acid receptor signaling in breast cancerR01CA253329 · NCI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI Katherine Loree Cook, Liza Makowski-Hayes · 2020 to 2026
$3.0M
Harnessing the Power of p53 with Panaxynol from American Ginseng to Suppress Colitis and Prevent Colon Cancer - admin suppR01CA246809 · NCI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI HOFSETH, LORNE J, MURPHY, ELIZABETH ANGELA · 2020 to 2024
$2.2M
HHS | NIH | National Cancer Institute (NCI) R01CA246809HHS | NIH | National Cancer Institute (NCI) R01CA253329HHS | NIH | National Cancer Institute (NCI) U01CA272541HHS | NIH | National Cancer Institute (NCI) U01CA272977NCI NIH HHS R01 CA246809NCI NIH HHS R01 CA253329NCI NIH HHS U01 CA272541NCI NIH HHS U01 CA272977U.S. Department of Defense (DOD) BC210715
6 · The paper itself

Abstract

The gut microbiome plays a critical role in the development, progression, and treatment of cancer. As interest in microbiome-immune-cancer interactions expands, the prevalence of fecal microbial transplant (FMT) models has increased proportionally. However, current literature does not provide adequate details or consistent approaches to allow for necessary rigor and experimental reproducibility. In this review, we evaluate key studies using FMT to investigate the relationship between the gut microbiome and various types of cancer. In addition, we will discuss the common pitfalls of these experiments and methods for improved standardization and validation as the field uses FMT with greater frequency. Finally, this review focuses on the impacts of the gut and extraintestinal microbes, prebiotics, probiotics, and postbiotics in cancer risk and response to therapy across a variety of tumor types.

Indexed as

Fecal Microbiota TransplantationGastrointestinal MicrobiomeNeoplasmsAnimalsFecesHumansProbioticscancerextraintestinal microbesfecal microbial transplantgut microbiomemicrobially derived metabolites

Identifiers

PMID39301964
PMCPMC11559651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.