Evidence map›Paper›PMID 39301907›Full record

ReviewCurrent cardiology reviews2025

Importance of Zinc Homeostasis for Normal Cardiac Rhythm.

Pejman Kokhabi, Reza Mollazadeh, Seyedeh Fatemeh Hejazi, Aida Hossein Nezhad, Hamidreza Pazoki-Toroudi

Abstract readReview
In one paragraph

Review in Current cardiology reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Pejman KokhabiSchool of Advanced Medical Sciences, Tehran Medical Branch, Islamic Azad University, Tehran, Iran.ORCID 0009-0005-7303-5399
Reza MollazadehDepartment of Cardiology, School of Medicine, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran.ORCID 0000-0002-2131-0409
Seyedeh Fatemeh HejaziSchool of Advanced Medical Sciences, Tonekabon Medical Branch, Islamic Azad University, Tonekabon, Iran.
Aida Hossein NezhadSchool of Advanced Medical Sciences, Tonekabon Medical Branch, Islamic Azad University, Tonekabon, Iran.
Hamidreza Pazoki-ToroudiDepartment of Physiology, Physiology Research Center, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.ORCID 0000-0001-7868-456X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current arrhythmia therapies such as ion channel blockers, catheter ablation, or implantable cardioverter defibrillators have limitations and side effects, and given the proarrhythmic risk associated with conventional, ion channel-targeted anti-arrhythmic drug therapies, a new approach to arrhythmias may be warranted. Measuring and adjusting the level of specific ions that impact heart rhythm can be a simple and low-complication strategy for preventing or treating specific arrhythmias. In addition, new medicines targeting these ions may effectively treat arrhythmias. Numerous studies have shown that intracellular and extracellular zinc concentrations impact the heart's electrical activity. Zinc has been observed to affect cardiac rhythm through a range of mechanisms. These mechanisms encompass the modulation of sodium, calcium, and potassium ion channels, as well as the influence on beta-adrenergic receptors and the enzyme adenylate cyclase. Moreover, zinc can either counteract or induce oxidative stress, hinder calmodulin or the enzyme Ca (

Indexed as

Arrhythmias, CardiacHeart RateHomeostasisZincAnimalsHumansZincarrhythmiaATP levelsheavy metalion channelstrace elementsZinc

Identifiers

PMID39301907
PMCPMC12060914

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.