Evidence map›Paper›PMID 39301839›Full record

ArticleArtificial organs2025

Cold atmospheric plasma therapy as a novel treatment for Berlin Heart EXCOR pediatric cannula infections.

Johanna Schachl, Markus Königshofer, Martin Stoiber, Martina Socha, Christian Grasl, Theodor Abart, Ina Michel-Behnke, Dominik Wiedemann, Julia Riebandt, Daniel Zimpfer and 1 more

Abstract readCase Reports
In one paragraph

Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Johanna SchachlDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0009-0009-5841-3602
Markus KönigshoferCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Martin StoiberCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Martina SochaDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Christian GraslCenter for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria.
Theodor AbartDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Ina Michel-BehnkeDepartment of Pediatric Cardiology, Medical University of Vienna, Vienna, Austria.
Dominik WiedemannDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Julia RiebandtDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Daniel ZimpferDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.
Thomas SchlöglhoferDepartment of Cardiac Surgery, Medical University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0003-4354-4860

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCold atmospheric plasma (CAP) therapy has been recognized as effective treatment option for reducing bacterial load in chronic wounds, such as adult ventricular assist device (VAD) driveline exit-site infections. Currently, there have been no reports on the safety and efficacy of CAP therapy for pediatric cannula infections and inflammations in paracorporeal pulsatile VADs.

methodsThe mechanical strength of Berlin Heart EXCOR cannulas were tested both before and after CAP treatment (SteriPlas, Adtec Healthcare Limited, UK) to prove material safety. A ring tensile test of 20 untreated and 20 CAP-treated (5 min) EXCOR cannulas (Ø12mm), assessed the force at the breaking point of the cannulas (F

resultsThe in vitro measurements revealed no statistically significant differences in mechanical strength between the control and CAP group for F

conclusionOverall, CAP therapy proved to be a safe and effective for treating EXCOR cannula exit-site wound healing disorders in one pediatric patient, but further studies should investigate this therapy in more detail.

Indexed as

CannulaCatheter-Related InfectionsHeart-Assist DevicesPlasma GasesProsthesis-Related InfectionsAdolescentHumansMaleTensile StrengthPlasma GasesBerlin Heart EXCORcold atmospheric plasma therapyinfectionmechanical circulatory supportventricular assist device

Identifiers

PMID39301839
PMCPMC11752981

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.