ArticleHuman brain mapping2024
Changes in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first-episode psychosis.
Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Structural neuroimaging correlates of semantic incoherence in schizophrenia.European archives of psychiatry and clinical neuroscience · 2026Article
- Disrupted hierarchical functional brain organization in affective and psychotic disorders: insights from functional brain gradients.Translational psychiatry · 2026Article
- Investigating acoustic startle priming-induced cortical network reorganization in post-stroke dysarthria: a fNIRS study.Biomedical optics express · 2026Article
- Spontaneous speech enables scalable digital phenotyping of physical functional deficits in aging.npj aging · 2026Article
- Reduced linguistic coherence in psychosis defies semantic similarity accounts and relates to altered large-scale cortical hierarchy.Scientific reports · 2026Article
- Brain function in language and associated networks in non- or minimally verbal children.Brain communications · 2026Article
- Syntactic network analysis in first-episode psychosis: toward generalizability.Schizophrenia (Heidelberg, Germany) · 2025Article
- The structure of spontaneous speech changes in Alzheimer's disease: Crosslingual evidence from English and Greek.PloS one · 2025Article
- Changes in the structure of spontaneous speech predict the disruption of hierarchical brain organization in first-episode psychosis.Human brain mapping · 2024Article
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5 authors.
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Abstract
Psychosis implicates changes across a broad range of cognitive functions. These functions are cortically organized in the form of a hierarchy ranging from primary sensorimotor (unimodal) to higher-order association cortices, which involve functions such as language (transmodal). Language has long been documented as undergoing structural changes in psychosis. We hypothesized that these changes as revealed in spontaneous speech patterns may act as readouts of alterations in the configuration of this unimodal-to-transmodal axis of cortical organization in psychosis. Results from 29 patients with first-episodic psychosis (FEP) and 29 controls scanned with 7 T resting-state fMRI confirmed a compression of the cortical hierarchy in FEP, which affected metrics of the hierarchical distance between the sensorimotor and default mode networks, and of the hierarchical organization within the semantic network. These organizational changes were predicted by graphs representing semantic and syntactic associations between meaningful units in speech produced during picture descriptions. These findings unite psychosis, language, and the cortical hierarchy in a single conceptual scheme, which helps to situate language within the neurocognition of psychosis and opens the clinical prospect for mental dysfunction to become computationally measurable in spontaneous speech.
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