Evidence map›Paper›PMID 39301638›Full record

ArticleMolecular medicine reports2024

Wnt7B enhances the osteogenic differentiation of lipopolysaccharide-stimulated human periodontal ligament stem cells and inhibits the M1 polarization of macrophages by binding FZD4.

Haijing Yang, Yan Zhang, Lu Zhang, Xiaojuan Tan, Min Zhi, Chunmei Wang

Abstract read
In one paragraph

Article in Molecular medicine reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haijing YangDepartment of Periodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin 300070, P.R. China.
Yan ZhangSchool of Nursing, Tianjin Medical University, Tianjin 300070, P.R. China.
Lu ZhangDepartment of Periodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin 300070, P.R. China.
Xiaojuan TanDepartment of Periodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin 300070, P.R. China.
Min ZhiDepartment of Periodontics, Tianjin Medical University School and Hospital of Stomatology, Tianjin 300070, P.R. China.
Chunmei WangSchool of Nursing, Tianjin Medical University, Tianjin 300070, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis, a common oral disease characterized by the progressive infiltration of bacteria, is a leading cause of adult tooth loss. Periodontal stem cells (PDLSCs) possess good self‑renewal and multi‑potential differentiation abilities to maintain the integrity of periodontal support structure and repair defects. The present study aimed to analyze the roles of Wnt7B and frizzled4 (FZD4) in the osteogenic differentiation and macrophage polarization during periodontitis using an

Indexed as

Cell DifferentiationFrizzled ReceptorsLipopolysaccharidesMacrophagesOsteogenesisPeriodontal LigamentStem CellsWnt ProteinsAdultCells, CulturedHumansPeriodontitisProtein BindingFrizzled ReceptorsFZD4 protein, humanLipopolysaccharidesWNT7B protein, humanWnt Proteinsdentistrymacrophage polarizationosteogenic differentiationperiodontitisperiodontologyWnt7B

Identifiers

PMID39301638
PMCPMC11413851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.