Evidence map›Paper›PMID 39301524›Full record

ArticleBiodesign research2024

Dynamic Gene Expression Mitigates Mutational Escape in Lysis-Driven Bacteria Cancer Therapy.

Filippo Liguori, Nicola Pellicciotta, Edoardo Milanetti, Sophia Xi Windemuth, Giancarlo Ruocco, Roberto Di Leonardo, Tal Danino

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biodesign research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Living Microbial Drugs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Filippo LiguoriDepartment of Physics, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0003-2859-6953
Nicola PellicciottaNANOTEC-CNR, Soft and Living Matter Laboratory, Institute of Nanotechnology, Rome, Italy.ORCID https://orcid.org/0000-0002-7105-9566
Edoardo MilanettiDepartment of Physics, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-3046-5170
Sophia Xi WindemuthDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Giancarlo RuoccoDepartment of Physics, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-2762-9533
Roberto Di LeonardoDepartment of Physics, Sapienza University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-5020-0663
Tal DaninoDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.ORCID https://orcid.org/0000-0003-2713-7659

Funding

Programmable encapsulation systems to improve delivery of therapeutic bacteriaR01EB034302 · NIBIB · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Nicholas Arpaia, Tal Danino · 2023 to 2026
$2.5M
NIBIB NIH HHS R01 EB034302
6 · The paper itself

Abstract

Engineered bacteria have the potential to deliver therapeutic payloads directly to tumors, with synthetic biology enabling precise control over therapeutic release in space and time. However, it remains unclear how to optimize therapeutic bacteria for durable colonization and sustained payload release. Here, we characterize nonpathogenic

Identifiers

PMID39301524
PMCPMC11411163

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.