Evidence map›Paper›PMID 39301312›Full record

ArticleJournal of the Endocrine Society2024

Usefulness of the Upright Posture Test in the Diagnosis of Primary Aldosteronism.

Nada Younes, Matthieu St-Jean, Marie-Josée Desrochers, Eric Therasse, Mathieu Latour, Isabelle Bourdeau, André Lacroix

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Primary aldosteronism.Nature reviews. Disease primers · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Subclinical primary aldosteronism.Archives of endocrinology and metabolism · 2025
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nada YounesDivision of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.ORCID https://orcid.org/0000-0002-3945-2325
Matthieu St-JeanDivision of Endocrinology, Department of Medicine, Centre hospitalier de l'Université de Sherbrooke, Sherbrooke, Québec, Canada, J1H 5H3.ORCID https://orcid.org/0000-0001-9791-2118
Marie-Josée DesrochersDivision of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.
Eric TherasseDepartment of Radiology, Centre de Recherche du Centre hospitalier de l'Université de Montréal, Université de Montréal, Québec, Canada, H2X 0A9.
Mathieu LatourDepartment of Pathology and Cellular Biology, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.
Isabelle BourdeauDivision of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.ORCID https://orcid.org/0000-0002-8000-4313
André LacroixDivision of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal, Montréal, Québec, Canada, H2X 0A9.ORCID https://orcid.org/0000-0003-4137-3025

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To assess the usefulness of the upright posture stimulation test (UPT) in the confirmation of primary aldosteronism (PA) in patients in whom saline tests (ST) were inconclusive. Methods: One hundred eighty-seven adult patients with possible PA were retrospectively included and compared to 25 control subjects. Blood samples were obtained after a 1-hour supine posture and during 2 hours of ambulation. An increase in plasma aldosterone concentration (PAC) ≥ 50% with a suppressed renin (≤10.1 ng/L; ≤1 ng/mL/hour) and a cortisol increase ≤50% were considered abnormal. Results: PA patients had higher basal PAC and lower basal direct renin concentration (DRC) ( Conclusion: UPT can be useful to confirm PA, particularly in patients with suspected false-negative ST.

Indexed as

confirmation testdiagnosisprimary aldosteronismsaline testsupright posture

Identifiers

PMID39301312
PMCPMC11411212

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.