Evidence map›Paper›PMID 39301289›Full record

ArticleFrontiers in cellular and infection microbiology2024

Intervention in gut microbiota increases intestinal γ-aminobutyric acid and alleviates anxiety behavior: a possible mechanism via the action on intestinal epithelial cells.

Mion Ikegami, Hikari Narabayashi, Kazuaki Nakata, Miyu Yamashita, Yutaka Sugi, Yushiro Fuji, Hiroshi Matsufuji, Gaku Harata, Kazutoyo Yoda, Kenji Miyazawa and 2 more

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Isolation and genetic analysis of anBiochemistry and biophysics reports · 2026
    Article
  5. Review
  6. Targeting the intestinal TLR4-GABAJournal of neuroinflammation · 2026
    Article
  7. Therapeutic potential ofMicrobiome research reports · 2026
    Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Characterization ofFoods (Basel, Switzerland) · 2025
    Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mion IkegamiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Hikari NarabayashiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Kazuaki NakataNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Miyu YamashitaNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Yutaka SugiCollege of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
Yushiro FujiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Hiroshi MatsufujiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Gaku HarataTechnical Research Laboratory, Takanashi Milk Products Co., Ltd, Yokohama, Kanagawa, Japan.
Kazutoyo YodaTechnical Research Laboratory, Takanashi Milk Products Co., Ltd, Yokohama, Kanagawa, Japan.
Kenji MiyazawaTechnical Research Laboratory, Takanashi Milk Products Co., Ltd, Yokohama, Kanagawa, Japan.
Yusuke NakanishiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.
Kyoko TakahashiNihon University Graduate School of Bioresource Sciences, Fujisawa, Kanagawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of the gut microbiota in the gut-brain axis has attracted attention in recent years. Some gut microbiota produces γ-aminobutyric acid (GABA), a major inhibitory neurotransmitter in mammals,

Indexed as

AnxietyEpithelial Cellsgamma-Aminobutyric AcidGastrointestinal MicrobiomeAnimalsBifidobacteriumHumansIntestinal MucosaMaleMiceMice, Inbred C57BLNeomycinProbioticsReceptors, GABAgamma-Aminobutyric AcidNeomycinReceptors, GABAgut-brain axisgut microbiotaintestinal epithelial cellprobioticsγ-aminobutyric acid

Identifiers

PMID39301289
PMCPMC11410766

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.