Evidence map›Paper›PMID 39301260›Full record

ArticleExperimental and therapeutic medicine2024

Clinical aspects and risks of the phenol/croton oil.

Ioannis E Liapakis, Georgios K Ismailos, Angelos Michail, Georgios P Tsakonis, Georgia Gloustianou, Ioannis Koliarakis, Apostolos D Mandrekas

Abstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ioannis E LiapakisOpsis Clinical Plastic and Reconstructive Surgery, 71304 Heraklion, Greece.
Georgios K IsmailosExperimental Research Center ELPEN, ELPEN Pharmaceuticals, 19009 Pikermi, Greece.
Angelos MichailMichail Clinic for Plastic and Reconstructive Surgery, 5961 BH Maastricht, The Netherlands.
Georgios P TsakonisTsakonis Plastic and Reconstructive Surgery Clinic, 12134 Athens, Greece.
Georgia GloustianouHistopathologic Diagnosis, 11521 Athens, Greece.
Ioannis KoliarakisSchool of Medicine, University of Crete, 71500 Heraklion, Greece.
Apostolos D MandrekasArtion Plastic Surgery Center, 15451 Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenol/croton oil is a unique chemical formulation promoting deep skin resurfacing and cellular renovation. Even though it has been used for decades in plastic surgery, the clinicopathological features, as well as the risks related to phenol/croton oil clinical application have not been thoroughly studied. The aim of the present study was to assess the effectiveness of the phenol/croton oil peel, the pathological characteristics from 1 patient at least and the emerging potential risks. A total of 64 patients were treated with phenol/croton oil peel between 2014 and 2023; in total, 21 of them underwent resurfacing at their oral area (upper/lower lips), 15 underwent resurfacing at their lower eyelid wrinkles, 22 patients underwent full face resurfacing, 2 patients were treated for their acne scars and additionally 4 patients were treated for multiple body seborrheic keratosis. The wrinkles, as well as the acne scars were markedly improved in all patients, the seborrheic keratosis was eliminated, while adverse events and undesired clinical manifestations related to peel intervention were mild and reversible for all patients. The application of phenol/croton oil constitutes an immensely powerful tool for deep chemical peeling and facial skin rejuvenation; nevertheless, it should be used cautiously due to its potential complications.

Indexed as

acne scarscroton oildeep chemical peelingkeratosisphenolskin agingwrinkles

Identifiers

PMID39301260
PMCPMC11412097

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.