Evidence map›Paper›PMID 39301195›Full record

ArticleBioelectronics in medicine2018

Block of motor nerve conduction via transcutaneous application of direct current.

Gustaf M Van Acker, Tina L Vrabec, Narendra Bhadra, John Chae, Kevin L Kilgore, Niloy Bhadra

Abstract read
In one paragraph

Article in Bioelectronics in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. A Cuff Lead for Delivering Ionic Direct Current (iDC) to Block Neural Activities of Sciatic Nerve.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gustaf M Van AckerMetroHealth Rehabilitation Institute of Ohio, The MetroHealth System & Case Western Reserve University, Cleveland, OH 44109, USA.
Tina L VrabecDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Narendra BhadraDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
John ChaeMetroHealth Rehabilitation Institute of Ohio, The MetroHealth System & Case Western Reserve University, Cleveland, OH 44109, USA.
Kevin L KilgoreDepartment of Orthopedics, The MetroHealth System, Cleveland, OH 44109, USA.
Niloy BhadraMetroHealth Rehabilitation Institute of Ohio, The MetroHealth System & Case Western Reserve University, Cleveland, OH 44109, USA.

Funding

Separated-interface Electrodes for use with High Frequency Nerve Conduction BlockR01NS074149 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI BHADRA, NARENDRA · 2011 to 2014
$1.4M
NINDS NIH HHS R01 NS074149
6 · The paper itself

Abstract

Aims: Nerve conduction block using implanted electrodes is being used increasingly for clinical applications. Alternatively, non-invasive electrical nerve block would be beneficial for applications including pain block and muscle spasticity. Here we developed a novel means of non-invasive electrical nerve conduction blockade - transcutaneous direct current block (tDCB) - that produces direct block of nerve conduction. Materials & Methods: In an Results: Partial-to-complete neuromotor block was achieved in all subjects using tDCB amplitudes at or below 20 mA, and complete block was achieved at amplitudes as low as 6 mA. Conclusions: Our results reveal that neuromotor activity can be rapidly, reliably and reversibly blocked using tDCB.

Indexed as

direct currentelectrical nerve blockneuromodulationnon-invasiveperipheral nervespasticitytranscutaneous

Identifiers

PMID39301195
PMCPMC11412303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.