Evidence map›Paper›PMID 39301108›Full record

ArticleOpen forum infectious diseases2024

Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection.

Nyasha V Dzavakwa, Victoria Simms, Celia L Gregson, Molly Chisenga, Suzanne Filteau, Lackson Kasonka, Katharina Kranzer, Hildah Banda-Mabuda, Hilda Mujuru, Nicol Redzo and 5 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nyasha V DzavakwaThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0003-3547-8146
Victoria SimmsThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-4897-458X
Celia L GregsonThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0001-6414-0529
Molly ChisengaUniversity Teaching Hospital, Women and Newborn Hospital, Lusaka, Zambia.ORCID https://orcid.org/0000-0003-0298-2397
Suzanne FilteauDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID https://orcid.org/0000-0002-1119-6825
Lackson KasonkaUniversity Teaching Hospital, Women and Newborn Hospital, Lusaka, Zambia.ORCID https://orcid.org/0000-0001-7525-2382
Katharina KranzerThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0001-5691-7270
Hildah Banda-MabudaUniversity Teaching Hospital, Women and Newborn Hospital, Lusaka, Zambia.
Hilda MujuruDepartment of Paediatrics, University of Zimbabwe, Harare, Zimbabwe.ORCID https://orcid.org/0000-0003-1615-3856
Nicol RedzoThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-9045-2160
Cynthia Mukwasi-KahariThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-7289-5152
Sarah L Rowland-JonesNuffield Department of Medicine, University of Oxford, Oxford, United Kingdom.ORCID https://orcid.org/0000-0001-5788-6998
Ulrich E SchaibleCellular Microbiology, Priority Research Area Infections, Research Centre Borstel, Leibniz Lung Centre & Leibniz Research Alliance INFECTIONS, Borstel, Germany.ORCID https://orcid.org/0000-0002-6638-7282
Rashida A FerrandThe Health Research Unit Zimbabwe (THRU-Zim), Biomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-7660-9176
VITALITY team

Funding

Wellcome Trust
6 · The paper itself

Abstract

Background: Stunting and pubertal delay are common among children growing up with human immunodeficiency virus (HIV) and are associated with bone and muscle impairments. We investigated factors associated with bone density and muscle function in adolescents living with HIV (ALWH). Methods: The VITALITY trial (PACTR202009897660297) investigated whether vitamin D and calcium supplementation improves musculoskeletal health among ALWH. A total of 842 ALWH aged 11-19 years, established on antiretroviral therapy (ART) for ≥6 months, were enrolled from HIV clinics in Zambia and Zimbabwe. Clinical history and examination were undertaken, and serum 25-hydroxyvitamin D Results: TBLH-BMD Conclusions: Deficits in bone density are common in ALWH. Vitamin D and calcium supplementation and promotion of exercise may improve musculoskeletal health among perinatally infected ALWH.

Indexed as

adolescentbone densityHIVmusculoskeletal healthvitamin d

Identifiers

PMID39301108
PMCPMC11411771

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.