Evidence map›Paper›PMID 39301094›Full record

ArticleClinical case reports2024

A patient with positive anti-IFN-γ autoantibody and monoclonal gammaglobulinemia masquerading as multiple myeloma: Case report and literature review.

Ran An, Zhiyin Liu, Fangxiu Luo, Zeying Yan, Ying Wang, Haimin Sun, Jie Tian, Yu Chen, Yubao Chen

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ran AnDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.ORCID https://orcid.org/0009-0005-1289-7577
Zhiyin LiuDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Fangxiu LuoDepartment of Pathology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Zeying YanDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Ying WangDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Haimin SunDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Jie TianDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Yu ChenDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.
Yubao ChenDepartment of Hematology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key Clinical Message: Adult-onset immunodeficiency (AOID) is an emerging acquired immunodeficiency, characterized by multiple opportunistic infections including non-tuberculous mycobacterium (NTM) due to the presence of anti-IFN-γ autoantibody (AIGA). This case highlights the challenges of accurate diagnosis of monoclonal gammaglobulinemia with NTM infection and favorable outcomes of anti-plasma cell therapy in AOID. Abstract: Adult-onset immunodeficiency (AOID) is an emerging acquired immunodeficiency due to anti-IFN-γ autoantibody (AIGA) with low morbidity, frequent disseminated infections, a prolonged course, difficult diagnosis and treatment, and a poor prognosis. Here, we report a patient with positive AIGA and monoclonal gammaglobulinemia who was mimicking symptomatic multiple myeloma and resulting in a non-tuberculous mycobacterial (NTM) infection. While he achieved an excellent therapeutic effect with anti-plasma cell therapy, it also serves as a warning that monoclonal gammaglobulinemia with NTM infection is easily misdiagnosed as symptomatic multiple myeloma, and the screening for AIGA should not be ignored in patients with NTM infection.

Indexed as

adult‐onset immunodeficiencyanti‐IFN‐γ autoantibodymonoclonal gammaglobulinemiamultiple myelomanon‐tuberculous mycobacterial infection

Identifiers

PMID39301094
PMCPMC11410870

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.