ArticleBiomicrofluidics2024
Insights into the fluid dynamics of bioaerosol formation in a model respiratory tract.
Article in Biomicrofluidics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Microfluidics and nanofluidics in India - some recent advancements and futuristic perspective.Biomicrofluidics · 2025Article
- Perspectives on physics-based one-dimensional modeling of lung physiology.Frontiers in physiology · 2025Article
- Computational modeling of cough-induced droplets and mucosal film dynamics in the upper airway for pulmonary disease classification.Frontiers in physiology · 2025Article
- Editorial: Translating biomechanics of the human airways for classification, diagnosis and treatment of pulmonary diseases.Frontiers in physiology · 2025Article
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Authors and funding
6 authors.
Funding
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Abstract
Bioaerosols produced within the respiratory system play an important role in respiratory disease transmission. These include infectious diseases such as common cold, influenza, tuberculosis, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among several others. It is, therefore, of immense interest to understand how bioaerosols are produced within the respiratory system. This has not been extensively investigated. The present study computationally investigates how bioaerosols are produced in a model respiratory tract due to hydrodynamic interactions between breathed air and a thin mucus layer, which lines the inner surface of the tract. It is observed that Kelvin-Helmholtz instability is established in the thin mucus layer due to associated fluid dynamics. This induces interfacial surface waves which fragment forming bioaerosols under certain conditions. A regime map is created-based on pertinent dimensionless parameters-to enable identification of such conditions. Analysis indicates that bioaerosols may be produced even under normal breathing conditions, contrary to expectations, depending on mucus rheology and thickness of the mucus layer. This is possible during medical conditions as well as during some treatment protocols. However, such bioaerosols are observed to be larger (
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