Evidence map›Paper›PMID 39300828›Full record

ArticleSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2024

Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence.

ZhiRong Liu, YuanYing Wang, ShiHao Wang, JiaXin Wu, Cui Jia, Xuan Tan, XinLian Liu, XinWei Huang, LuShun Zhang

RetractedAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Unraveling the causative connection between urticaria, inflammatory cytokines, and mental disorders: Perspectives from genetic evidence.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

ZhiRong LiuDepartment of General Surgery, Chengdu Second People's Hospital, Chengdu, China.
YuanYing WangGraduate School, Chengdu Medical College, Chengdu, China.
ShiHao WangSchool of Biological Science and Technology, Chengdu Medical College, Chengdu, China.
JiaXin WuGraduate School, Chengdu Medical College, Chengdu, China.
Cui JiaDevelopment and Regeneration Key Laboratory of Sichuan Province, Institute of Neuroscience, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
Xuan TanSchool of Biological Science and Technology, Chengdu Medical College, Chengdu, China.
XinLian LiuDevelopment and Regeneration Key Laboratory of Sichuan Province, Institute of Neuroscience, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.
XinWei HuangShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
LuShun ZhangDevelopment and Regeneration Key Laboratory of Sichuan Province, Institute of Neuroscience, Department of Pathology and Pathophysiology, Chengdu Medical College, Chengdu, China.ORCID https://orcid.org/0000-0001-6094-2460

Funding

National Natural Science Foundation of China No. 81401161National Program for College Student Innovation and Entrepreneurship Training 202213705036The Development and Regeneration Key Laboratory of Sichuan Province SYS13-006The Provincial Program for College Student Innovation and Entrepreneurship Training in Sichuan S202313705089The Provincial Program for College Student Innovation and Entrepreneurship Training in Sichuan S202413705092
6 · The paper itself

Abstract

backgroundThe genetic association between urticaria and mental disorders and whether inflammatory cytokines mediate this process remains unclear. MATERIALS AND

methodsA Mendelian randomization (MR) approaches to elucidate the causal relationship between urticaria and mental disorders and to validate the mediation of inflammatory cytokines. Genome-wide association study (GWAS) databases used were obtained from Psychiatric Genomics Cooperation (PGC), GWAS Catalog, and FinnGen Consortium. Our study was conducted using inverse variance weighted (IVW) and Bayesian weighted MR (BWMR) methods for joint analysis.

resultsThe MR results showed that urticaria increased the risk of attention deficit hyperactivity disorder (ADHD) (odds ratio [OR]

conclusionsOur study reveals a causal relationship between urticaria and the increased risk of mental disorders. We suggest that the treatment of urticaria could incorporate psychiatric interventions and mental health assessment of patients.

Indexed as

Attention Deficit Disorder with HyperactivityCytokinesGenome-Wide Association StudyMendelian Randomization AnalysisMental DisordersUrticariaBipolar DisorderGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotideCytokinescausal associationinflammatory cytokinesMendelian randomizationmental disordersurticaria

Identifiers

PMID39300828
PMCPMC11413335

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.