Evidence map›Paper›PMID 39300579›Full record

ArticleStem cell research & therapy2024

Therapeutic efficacy and in vivo distribution of human umbilical cord-derived mesenchymal stem cell spheroids transplanted via B-Ultrasound-guided percutaneous portal vein puncture in rhesus monkey models of liver fibrosis.

Shanshan Li, Xufeng Fu, Junfeng Wang, Hongju Yang, Dan Wang, Xudong Dong, Yanchao Duan, Hong Wang, Yaping Yan, Wei Si

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shanshan Li *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Xufeng Fu *State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Junfeng Wang *Department of Hepatic and Bile Duct Surgery, The First People's Hospital of Yunnan Province, Kunming, 650105, China.
Hongju YangGeriatric Medical Center, Division of geriatric Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Dan WangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Xudong DongDepartment of Obstetrics, The First People's Hospital of Yunnan Province, Kunming, 650105, China.
Yanchao DuanState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Hong WangState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China.
Yaping YanState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China. yanyp@lpbr.cn.
Wei SiState Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, 650504, China. siw@lpbr.cn.ORCID 0000-0003-0861-0682

Funding

Long Distance Caregiving: Unique Challenges and Service NeedsR21AG050018 · NIA · FORDHAM UNIVERSITY · PI HOROWITZ, AMY · 2016 to 2017
$433k
Famous Medical Specialist of High-level Talent Training Support Program of Yunnan Province RLMY20190004National Key Research and Development Program of China 2018YFA0801400Natural Science Foundation of Yunnan Province 202202AG050018NIA NIH HHS R21 AG050018Yunnan Health Training Project of High Level Talents L-2019016Yunnan High-level Talent Cultivation Support Plan of Famous Doctor Project KH-SWR-MY-2020-001Yunnan Provincial Key Research and Development Plan 202403AC100020
6 · The paper itself

Abstract

backgroundLiver fibrosis can progress to end-stage cirrhosis and liver cancer. Mesenchymal stem cells (MSCs) were considered the most promising therapeutic strategy, but most of the MSCs injected intravenously traditionally are trapped in the lungs, rapidly reducing their survival ability. MSC spheroids cultured in 3D have shown higher tolerance to fluid shear stress and better survival than dissociated MSCs. Simulating the route of orthotopic liver transplantation, transplanting MSC spheroids into the liver via hepatic portal vein may impact superior therapeutic effects.

methodsIn the present study, human umbilical cord-derived MSC spheroids (hUC-MSC

resultsWe found that hUC-MSC

conclusionsThis study reveals the distributions of transplanted hUC-MSC

Indexed as

Liver CirrhosisMacaca mulattaMesenchymal Stem CellsMesenchymal Stem Cell TransplantationPortal VeinUmbilical CordAnimalsDisease Models, AnimalHumansLiverSpheroids, CellularUltrasonographyCell tracing in vivohUC-MSC spheroidsLiver fibrosisRhesus monkeyTGF-β1/Smad signaling pathway

Identifiers

PMID39300579
PMCPMC11414180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.