Evidence map›Paper›PMID 39300570›Full record

ArticleVeterinary research2024

Duck hepatitis A virus utilizes PCBP2 to facilitate viral translation and replication.

Chenxia Xu, Yurui Jiang, Mingshu Wang, Anchun Cheng, Wei Zhang, Xumin Ou, Di Sun, Qiao Yang, Ying Wu, Bin Tian and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chenxia Xu *Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Yurui Jiang *Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Mingshu Wang *Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Anchun ChengInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China. chenganchun@vip.163.com.ORCID http://orcid.org/0000-0001-6093-353X
Wei ZhangSinopharm Yangzhou VAC Biological Engineering Co., Ltd., Yangzhou, 225100, China.
Xumin OuInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Di SunInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Qiao YangInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Ying WuInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Bin TianInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Yu HeInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Zhen WuInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Shaqiu ZhangInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Xinxin ZhaoInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Juan HuangInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Dekang ZhuInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Shun ChenInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Mafeng LiuInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.
Renyong JiaInstitute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, 611130, China.

Funding

China Agriculture Research System CARS-42-17Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System SCCXTD-2020-18
6 · The paper itself

Abstract

Duck hepatitis A virus type 1 (DHAV-1) is an important member of the Picornaviridae family that causes highly fatal hepatitis in ducklings. Since picornaviruses have small genomes with limited coding capacity, they must utilize host proteins for viral cap-independent translation and RNA replication. Here, we report the role of duck poly(rC)-binding protein 2 (PCBP2) in regulating the replication and translation of DHAV-1. During DHAV-1 infection, PCBP2 expression was upregulated. A biotinylated RNA pull-down assay revealed that PCBP2 positively regulates DHAV-1 translation through specific interactions with structural domains II and III of the DHAV-1 internal ribosome entry site (IRES). Further studies revealed that PCBP2 promotes DHAV-1 replication via an interaction of its KH1 domain (aa 1-92) with DHAV-1 3D

Indexed as

DucksHepatitis Virus, DuckPicornaviridae InfectionsPoultry DiseasesRNA-Binding ProteinsVirus ReplicationAnimalsHepatitis, Viral, AnimalProtein BiosynthesisRNA-Binding Proteins3DpolDHAV-1IRESPCBP2replicationtranslation

Identifiers

PMID39300570
PMCPMC11414061

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.