Evidence map›Paper›PMID 39300541›Full record

ArticleThrombosis journal2024

A single-center study of reference intervals for TAT, PIC, TM and t-PAIC in healthy older Chinese adults.

Lei Zhang, Yiming Chen, Rong Hu, Hua Chen, Xu Peng, Hui Yuan

Abstract read
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Article in Thrombosis journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Lei ZhangDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, China.
Yiming ChenCapital Medical University, Beijing, China.
Rong HuHealth Examination Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Hua ChenDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, China.
Xu PengDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, China.
Hui YuanDepartment of Clinical Laboratory, Beijing Anzhen Hospital, Capital Medical University, No.2 Anzhen Road, Beijing, China. 18911662931@189.cn.

Funding

the National Key Research and Development Program 2022YFC2009600, 2022YFC2009602
6 · The paper itself

Abstract

objectiveTo explore the distribution of thrombin-antithrombin complex (TAT), plasmin-α2-antiplasmin inhibitor complex (PIC), thrombomodulin (TM), and tissue plasminogen activator-inhibitor complex (t-PAIC) in healthy older Chinese adults, and establish the reference intervals (RIs).

methodsThe Biotech Shine i2900 chemiluminescence immune assay was used to measure the plasma concentrations of TAT, PIC, TM, and t-PAIC in 1628 adults ≥ 60 years. The RIs were established using the 2.5th and 97.5th percentiles of the distribution.

resultsTAT levels were lower in males than females across all ages. Differences between the ages of 60-79 and ≥ 80 in both sex groups were statistically significant, with an upward trend with age. PIC levels showed no difference between the sexes but increased with age in both groups. TM levels did not differ between the sex groups, with slight fluctuation with age. The level in females aged 60-69 was slightly higher than that in the other groups; the difference was statistically significant. T-PAIC levels were not significantly different between the sex groups, with less fluctuation with sex and age. The level in males ≥ 80 years old was slightly lower than that in the other groups; the difference was statistically significant. The RIs for all markers in healthy older Chinese adults were determined and statistically reported by age and sex. For TAT, the RIs for males aged 60-79 and ≥ 80 are 0.51-2.30 ng/mL and 0.88-3.72 ng/mL, respectively, whereas for females aged 60-79 and ≥ 80, the RIs are 0.68-2.82 ng/mL and 1.02-3.67 ng/mL, respectively. For PIC, the RIs for the age groups 60-69, 70-79, and ≥ 80 are 0.10-0.89 µg/mL, 0.12-1.00 µg/mL, and 0.21-1.04 µg/mL, respectively. The RI of TM for females aged 60-69 is 3.32-13.22 TU/mL, whereas it is 2.96-13.26 TU/mL for the other groups. The RI of t-PAIC for males aged ≥ 80 is 1.63-10.68 ng/mL, whereas it is 2.33-11.34 ng/mL for the other groups.

conclusionsDiscrepancies exist in thrombus markers among different sex and age groups. The RIs of TAT, PIC, TM and t-PAIC for healthy older Chinese adults were successfully established.

Indexed as

AgedPlasmin-α2-antiplasmin inhibitor complexReference intervalThrombin–antithrombin complexThrombomodulinTissue plasminogen activator-inhibitor complex

Identifiers

PMID39300541
PMCPMC11411837

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