Evidence map›Paper›PMID 39300515›Full record

ArticleWorld journal of surgical oncology2024

Long non-coding RNA PVT1 regulates TGF-β and promotes the proliferation, migration and invasion of hypopharyngeal carcinoma FaDu cells.

Yan Zhao, Lei Zhao, Maocai Li, Zhen Meng, Song Wang, Jun Li, Lianqing Li, Lili Gong

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yan ZhaoDepartment of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Liaocheng, Shandong, China.
Lei ZhaoDepartment of Otorhinolaryngology, Heze Municipal Hospital, Heze, Shandong, China.
Maocai LiDepartment of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China.
Zhen MengBiomedical Laboratory, Medical School of Liaocheng University, Liaocheng, Shandong, China.
Song WangPrecision Biomedical Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Jun LiPrecision Biomedical Laboratory, Liaocheng People's Hospital, Liaocheng, Shandong, China.
Lianqing LiDepartment of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China. lilianqing1979@163.com.
Lili GongDepartment of Otorhinolaryngology Head and Neck Surgery, Liaocheng People's Hospital, No.67, Dongchang West Road, Liaocheng, Shandong, 252000, China. gll79wm@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypopharyngeal carcinoma is one of the malignant tumors of the head and neck with a particularly poor prognosis. Recurrence and metastasis are important reasons for poor prognosis of hypopharyngeal cancer patients, and malignant proliferation, migration, and invasion of tumor cells are important factors for recurrence and metastasis of hypopharyngeal cancer. Therefore, elucidating hypopharyngeal cancer cells' proliferation, migration, and invasion mechanism is essential for improving diagnosis, treatment, and prognosis. Plasmacytoma Variant Translocation 1 (PVT1) is considered a potential diagnostic marker and therapeutic target for tumors. However, it remains unclear whether PVT1 is related to the occurrence and development of hypopharyngeal cancer and its specific mechanism. In this study, the promoting effect of PVT1 on the proliferation, migration, and invasion of hypopharyngeal carcinoma FaDu cells was verified by cell biology experiments and animal studies, and it was found that PVT1 inhibited the expression of TGF-β, suggesting that PVT1 may regulate the occurrence and development of hypopharyngeal carcinoma FaDu cells through TGF-β.

Indexed as

Cell MovementCell ProliferationGene Expression Regulation, NeoplasticHypopharyngeal NeoplasmsNeoplasm InvasivenessRNA, Long NoncodingAnimalsApoptosisBiomarkers, TumorCarcinoma, Squamous CellCell Line, TumorFemaleHumansMiceMice, Inbred BALB CMice, NudeBiomarkers, TumorPVT1 long-non-coding RNA, humanRNA, Long NoncodingTransforming Growth Factor betaFaDu cellsHypopharyngeal carcinomaLong noncoding RNA PVT1Transforming growth factor-β

Identifiers

PMID39300515
PMCPMC11414033

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