Evidence map›Paper›PMID 39300351›Full record

ArticleBMC infectious diseases2024

Latent tuberculosis infection and diagnostic performance of the tuberculin skin test among type 2 diabetics in Sana'a city, Yemen.

Rashad Abdul-Ghani, Asmaa Al-Awadi, Nuha Al-Aghbari, Abdullah A Al-Mikhlafy, Sadeq S Abdulmoghni, Sami S Al-Dobai, Nedal F Nauman

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Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Rashad Abdul-GhaniDepartment of Medical Parasitology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. rashadqb@yahoo.com.
Asmaa Al-AwadiDepartment of Microbiology, Faculty of Medicine and Health Sciences, University of Science and Technology (USTY), Sana'a, Yemen.
Nuha Al-AghbariDepartment of Community Medicine, Faculty of Medicine and Health Sciences, University of Science and Technology (USTY), Sana'a, Yemen.
Abdullah A Al-MikhlafyDepartment of Community Medicine, Faculty of Medicine and Health Sciences, University of Science and Technology (USTY), Sana'a, Yemen.
Sadeq S AbdulmoghniDepartment of Physiology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
Sami S Al-DobaiAULAQI Specialized Medical Laboratories, Sana'a, Yemen.
Nedal F NaumanAULAQI Specialized Medical Laboratories, Sana'a, Yemen.

Funding

WHO/EMRO/TDR AP-22-00710
6 · The paper itself

Abstract

backgroundTuberculosis (TB) is one of the most widespread infectious diseases worldwide, typically persisting in the body as a latent TB infection (LTBI). Patients with type 2 diabetes have an increased risk of LTBI progressing to active TB. Therefore, this study determined the prevalence and predictors of LTBI and assessed the agreement between tuberculin skin test (TST) and interferon-gamma release assay (IGRA) in diagnosing LTBI among type 2 diabetics in Sana'a city, Yemen.

methodsA cross-sectional study was conducted among 150 type 2 diabetics in private health facilities in Sana'a in 2023. Data about demographics, diabetes-related characteristics, and potential risk factors for LTBI were collected using a structured questionnaire. Patients were then screened for LTBI using TST and IGRA. Univariate analysis was used to identify LTBI-associated risk factors, and multivariable binary logistic regression was used to identify independent predictors of LTBI. The agreement between TST and IGRA for diagnosing LTBI was assessed using Cohen's kappa coefficient (κ).

resultsLTBI was prevalent among 29.3% of type 2 diabetics using both types of tests (25.3% with IGRA and 21.3% with TST). Male gender was an independent predictor of LTBI (AOR = 4.4, 95% confidence interval: 1.30-15.08; P = 0.018). However, being employed (AOR = 0.3, 95% CI: 0.09-0.75; P = 0.013) and longer duration since diabetes diagnosis (AOR = 0.3, 95% CI: 0.12-0.98; P = 0.046) were identified as predictors of lower LTBI risk. The agreement between TST and IGRA for the diagnosis of LTBI was 88%, with a good and statistically significant agreement between the two test types (κ = 0.670; P < 0.001).

conclusionsLTBI is common among type 2 diabetics seeking medical care in Sana'a city, with about one-third of them possibly being latently infected. A higher LTBI risk can be predicted among males, while a lower risk can be predicted among those employed or being diagnosed with diabetes for at least five years. The TST shows good agreement with IGRA in diagnosing LTBI among type 2 diabetics, supporting its continued use as a cost-effective and easily accessible test for diagnosing LTBI in the country.

Indexed as

Diabetes Mellitus, Type 2Interferon-gamma Release TestsLatent TuberculosisTuberculin TestAdultAgedCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceRisk FactorsYemenInterferon-gamma release assayLatent tuberculosis infectionTuberculin skin testType 2 diabeticsYemen

Identifiers

PMID39300351
PMCPMC11411833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.