Evidence map›Paper›PMID 39300319›Full record

ArticleCellular & molecular immunology2024

Hepatocellular carcinoma-specific epigenetic checkpoints bidirectionally regulate the antitumor immunity of CD4 + T cells.

Shuai Wang, Lijun Meng, Nan Xu, Huan Chen, Zhaofeng Xiao, Di Lu, Xiaohui Fan, Limin Xia, Jun Chen, Shusen Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Shuai Wang *Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou First People's Hospital, Hangzhou, 310006, China. wmmkao2@163.com.
Lijun Meng *Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou First People's Hospital, Hangzhou, 310006, China.
Nan Xu *Zhejiang University School of Medicine, Hangzhou, 310000, Zhejiang, China.
Huan Chen *The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Zhaofeng Xiao *The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, China.
Di LuSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, 310059, Zhejiang, China.
Xiaohui FanNational Key Laboratory of Chinese Medicine Modernization, Innovation Center of Yangtze River Delta, Zhejiang University, Jiaxing, 314103, China.ORCID 0000-0002-6336-3007
Limin XiaState Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, 710032, China.ORCID 0000-0002-6327-6034
Jun ChenNHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou China, Hangzhou, China.
Shusen ZhengNHC Key Laboratory of Combined Multi-Organ Transplantation Hangzhou China, Hangzhou, China.ORCID 0000-0003-1459-8261
Qiang WeiSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, 310059, Zhejiang, China.ORCID 0000-0003-1935-520X
Xuyong WeiKey Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province, Hangzhou First People's Hospital, Hangzhou, 310006, China. 1315009@zju.edu.cn.
Xiao XuSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, 310059, Zhejiang, China. zjxu@zju.edu.cn.ORCID 0000-0002-2761-2811

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81930016
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is a highly malignant tumor with significant global health implications. The role of CD4

Indexed as

Carcinoma, HepatocellularCD4-Positive T-LymphocytesEpigenesis, GeneticLiver NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorGene Expression Regulation, NeoplasticHigh Mobility Group ProteinsHumansLymphocyte ActivationMiceMice, Inbred C57BLTumor MicroenvironmentHigh Mobility Group ProteinsTOX protein, humanARID1AExhaustionMATR3TconvTOX

Identifiers

PMID39300319
PMCPMC11528031

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.