Evidence map›Paper›PMID 39300280›Full record

ArticleFEBS letters2024

The splicing factor hnRNPL demonstrates conserved myocardial regulation across species and is altered in heart failure.

Isabelle Draper, Wanting Huang, Suchita Pande, Aaron Zou, Timothy D Calamaras, Richard H Choe, Ana Correia-Branco, Ariel L Mei, Howard H Chen, Hannah R Littel and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Isabelle DraperMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Wanting HuangMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Suchita PandeMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Aaron ZouMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Timothy D CalamarasMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Richard H ChoeMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Ana Correia-BrancoMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0001-5353-9665
Ariel L MeiMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Howard H ChenMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.
Hannah R LittelGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Mekala GunasekaranGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Natalya M WellsGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Christine C BruelsGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Audrey L DaughertyGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Matthew J WolfDivision of Cardiology, University of Virginia, Charlottesville, VA, USA.
Peter B KangGreg Marzolf Jr. Muscular Dystrophy Center, Department of Neurology, and Institute for Translational Neuroscience, University of Minnesota, Minneapolis, MN, USA.ORCID https://orcid.org/0000-0002-4270-7325
Vicky K YangCummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.
Donna K SlonimDepartment of Computer Science, Tufts University, Medford, MA, USA.
Mary C WallingfordMother Infant Research Institute, Tufts Medical Center, Boston, MA, USA.
Robert M BlantonMolecular Cardiology Research Institute, Tufts Medical Center, Boston, MA, USA.ORCID https://orcid.org/0000-0002-6837-2076

Funding

Investigating Mixed Lineage Kinase 3 as a blood pressure-independent protein kinase G1 effector in heart failureR01HL162919 · NHLBI · TUFTS MEDICAL CENTER · PI Robert Morris Blanton · 2022 to 2026
$3.9M
Multiplexed Molecular Imaging of Cell Death PathwaysR00HL121152 · NHLBI · TUFTS MEDICAL CENTER · PI CHEN, HOWARD H. · 2017 to 2019
$747k
Naturally occurring canine myxomatous mitral valve disease as a large animal model for human non-syndromic mitral valve prolapseK01OD028205 · OD · TUFTS UNIVERSITY BOSTON · PI YANG, VICKY K. · 2019 to 2023
$691k
American Heart Association 932792Foundation for the National Institutes of Health 1R01HL162919Foundation for the National Institutes of Health K00/R00HL121152NHLBI NIH HHS R00 HL121152NHLBI NIH HHS R01 HL162919NIH HHS K01 OD028205
6 · The paper itself

Abstract

Heart failure (HF) is highly prevalent. Mechanisms underlying HF remain incompletely understood. Splicing factors (SF), which control pre-mRNA alternative splicing, regulate cardiac structure and function. This study investigated regulation of the splicing factor heterogeneous nuclear ribonucleoprotein-L (hnRNPL) in the failing heart. hnRNPL protein increased in left ventricular tissue from mice with transaortic constriction-induced HF and from HF patients. In left ventricular tissue, hnRNPL was detected predominantly in nuclei. Knockdown of the hnRNPL homolog Smooth in Drosophila induced cardiomyopathy. Computational analysis of predicted mouse and human hnRNPL binding sites suggested hnRNPL-mediated alternative splicing of tropomyosin, which was confirmed in C2C12 myoblasts. These findings identify hnRNPL as a sensor of cardiac dysfunction and suggest that disturbances of hnRNPL affect alternative splicing in HF.

Indexed as

Alternative SplicingHeart FailureMyocardiumAnimalsCell LineDrosophila ProteinsHeterogeneous-Nuclear RibonucleoproteinsHumansMaleMiceMice, Inbred C57BLTropomyosinDrosophila ProteinsHeterogeneous-Nuclear RibonucleoproteinsTropomyosincardiomyopathyheart failurehnRNPLmRNA splicingsplicing factors

Identifiers

PMID39300280
PMCPMC11560511

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.