Evidence map›Paper›PMID 39300259›Full record

ArticleCommunications biology2024

Lipophilic compounds restore function to neurodevelopmental-associated KCNQ3 mutations.

Michaela A Edmond, Andy Hinojo-Perez, Mekedlawit Efrem, Lin Yi-Chun, Iqra Shams, Sebastien Hayoz, Alicia de la Cruz, Marta E Perez Rodriguez, Maykelis Diaz-Solares, Derek M Dykxhoorn and 2 more

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Voltage-sensor conformational microenvironments encode isoform-selective ion channel activation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michaela A Edmond *Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Andy Hinojo-Perez *Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Mekedlawit EfremDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
Lin Yi-ChunDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.
Iqra ShamsDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Sebastien HayozDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Alicia de la CruzDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Marta E Perez RodriguezDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.ORCID 0009-0005-7723-7860
Maykelis Diaz-SolaresDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Derek M DykxhoornJohn P. Hussman Institute for Human Genomics, John T. Macdonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL, USA.
Yun Lyna LuoDepartment of Biotechnology and Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, CA, USA.ORCID 0000-0003-3581-754X
Rene Barro-SoriaDepartment of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA. rbarro@med.miami.edu.ORCID 0000-0003-4804-2739

Funding

Molecular Mechanisms of Epilepsy-Causing Mutations in IKM channels: Anti-epileptic effect of Lipophilic compounds.R01NS110847 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI BARRO-SORIA, RENE · 2020 to 2024
$1.7M
NINDS NIH HHS R01 NS110847
6 · The paper itself

Abstract

A major driver of neuronal hyperexcitability is dysfunction of K

Indexed as

KCNQ3 Potassium ChannelMolecular Dynamics SimulationMutationNeurodevelopmental DisordersAnimalsHEK293 CellsHumansIon Channel GatingMembrane PotentialsKCNQ3 Potassium ChannelKCNQ3 protein, human

Identifiers

PMID39300259
PMCPMC11413209

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.