Evidence map›Paper›PMID 39300229›Full record

ArticleNature chemical biology2025

A tRNA modification with aminovaleramide facilitates AUA decoding in protein synthesis.

Kenjyo Miyauchi, Satoshi Kimura, Naho Akiyama, Kazuki Inoue, Kensuke Ishiguro, Thien-Son Vu, Veerasak Srisuknimit, Kenta Koyama, Gosuke Hayashi, Akiko Soma and 5 more

Abstract read
In one paragraph

Article in Nature chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Compendium of RNA modifications for bacterial stress adaptation.Microbiology and molecular biology reviews : MMBR · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kenjyo Miyauchi *Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4075-7660
Satoshi Kimura *Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-3555-5877
Naho Akiyama *Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-4790-7203
Kazuki InoueDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Kensuke IshiguroDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-6651-1960
Thien-Son VuDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Veerasak SrisuknimitDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0002-0130-153X
Kenta KoyamaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Gosuke HayashiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Akiko SomaGraduate School of Horticulture, Chiba University, Matsudo, Japan.
Asuteka NagaoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Mikako ShirouzuLaboratory for Protein Functional and Structural Biology, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.ORCID 0000-0002-7997-2149
Akimitsu OkamotoDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.ORCID 0000-0002-7418-6237
Matthew K WaldorDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA. mwaldor@bwh.harvard.edu.ORCID 0000-0003-1843-7000
Tsutomu SuzukiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. ts@chembio.t.u-tokyo.ac.jp.ORCID 0000-0002-9731-1731

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Molecular Biology and Virulence of CTX PhageR37AI042347 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WALDOR, MATTHEW K · 2008 to 2017
$3.8M
Japan Agency for Medical Research and Development (AMED) JP223fa627001MEXT | Japan Society for the Promotion of Science (JSPS) 13J09842MEXT | Japan Society for the Promotion of Science (JSPS) 18H05272MEXT | Japan Society for the Promotion of Science (JSPS) 22K06075MEXT | Japan Society for the Promotion of Science (JSPS) 23KJ0409MEXT | Japan Society for the Promotion of Science (JSPS) 26113003MEXT | Japan Society for the Promotion of Science (JSPS) 26220205MEXT | JST | Exploratory Research for Advanced Technology (ERATO) JPMJER2002NIAID NIH HHS R01 AI042347NIAID NIH HHS R37 AI042347U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI-042347
6 · The paper itself

Abstract

Modified tRNA anticodons are critical for proper mRNA translation during protein synthesis. It is generally thought that almost all bacterial tRNAs

Indexed as

Protein BiosynthesisRNA, TransferAnticodonCodonCryoelectron MicroscopyCytidineIsoleucineModels, MolecularNucleic Acid ConformationAnticodonCodonCytidineIsoleucineRNA, Transfer

Identifiers

PMID39300229
PMCPMC11938285

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.