Evidence map›Paper›PMID 39300178›Full record

ArticleScientific reports2024

Proteomic analysis illustrates the potential involvement of motor proteins in cleft palate development.

Zijian Huang, Chuzhao Zhang, Meng Sun, Aiwei Ma, Liyun Chen, Wenshi Jiang, Mengjing Xu, Xujue Bai, Jianda Zhou, Wancong Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zijian Huang *Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Chuzhao Zhang *Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Meng Sun *Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Aiwei Ma *Department of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Liyun ChenDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Wenshi JiangDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Mengjing XuDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Xujue BaiDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China.
Jianda ZhouDepartment of Plastic and Reconstructive Surgery, Central South University Third Xiangya Hospital, Changsha, 410013, Hunan, China.
Wancong ZhangDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China. martine2007@sina.com.
Shijie TangDepartment of Plastic Surgery and Burn Center, Second Affiliated Hospital, Shantou University Medical College, DongXiaBei Road, Shantou, 515000, Guangdong, China. sjtang3@stu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cleft palate (CP) is a congenital condition characterized by a complex etiology and limited diagnostic and therapeutic options. In this study, we delved into the molecular mechanisms associated with retinoic acid (RA)-induced CP in Kun Ming mice. Proteomic analysis of control and RA-induced CP samples at embryonic day 15.5 revealed 25 upregulated and 19 downregulated proteins. Further analysis identified these differentially expressed proteins (DEPs) as being involved in extracellular matrix organization, actin cytoskeleton, and myosin complex. Moreover, these DEPs were found to be enriched in pathways related to motor protein activity and extracellular matrix-receptor interaction. Protein-protein interaction network analysis identified 10 hub proteins, including motor proteins and ECM-related proteins, which exhibited higher expression levels in CP compared to control tissues. These findings provide insights into the molecular mechanisms underlying CP and highlight potential targets for diagnostic and therapeutic purposes.

Indexed as

Cleft PalateProtein Interaction MapsProteomicsTretinoinAnimalsDisease Models, AnimalFemaleGene Expression Regulation, DevelopmentalMiceProteomeProteomeTretinoinCleft palateDifferentially expressed proteinsMotor proteinsProteomicsRetinoic acid

Identifiers

PMID39300178
PMCPMC11413370

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.