Evidence map›Paper›PMID 39300138›Full record

ArticleCommunications biology2024

A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D

Jocelyn A Ricard, Loïc Labache, Ashlea Segal, Elvisha Dhamala, Carrisa V Cocuzza, Grant Jones, Sarah W Yip, Sidhant Chopra, Avram J Holmes

Erratum issuedAbstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Jocelyn A RicardStanford Neurosciences Interdepartmental Program, Stanford University School of Medicine, Stanford, CA, USA. ricard@stanford.edu.ORCID http://orcid.org/0000-0001-9605-9389
Loïc LabacheDepartment of Psychiatry, Brain Health Institute, Rutgers University, NJ, USA.ORCID http://orcid.org/0000-0002-5733-0743
Ashlea SegalDepartment of Neuroscience, Yale University, New Haven, CT, USA.
Elvisha DhamalaFeinstein Institutes for Medical Research, Northwell Health, Manhasset, New York, USA.
Carrisa V CocuzzaDepartment of Psychiatry, Brain Health Institute, Rutgers University, NJ, USA.
Grant JonesDepartment of Psychology, Harvard University, Cambridge, MA, USA.
Sarah W YipDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2293-2864
Sidhant Chopra *Department of Psychiatry, Brain Health Institute, Rutgers University, NJ, USA. sc2773@rwjms.rutgers.edu.ORCID http://orcid.org/0000-0003-0866-3477
Avram J Holmes *Department of Psychiatry, Brain Health Institute, Rutgers University, NJ, USA. avram.holmes@rutgers.edu.ORCID http://orcid.org/0000-0001-6583-803X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Integrative analysis of genomics and imaging data from the BRAIN Initiative and other public data sourcesRF1MH123245 · NIMH · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, HOLMES, AVRAM J · 2021 to 2021
$1.3M
NCATS NIH HHS UL1 TR001863NIMH NIH HHS R01 MH120080NIMH NIH HHS RF1 MH123245U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH120080
6 · The paper itself

Abstract

The biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. Prior work on the development and maintenance of substance use has largely focused on cortico-striatal circuits, with relatively less attention on alterations within and across large-scale functional brain networks, and associated aspects of the dopamine system. Here, we characterize patterns of functional connectivity in cocaine use disorder and their spatial association with neurotransmitter receptor densities and transporter bindings assessed through PET. Profiles of functional connectivity in cocaine use disorder reliably linked with spatial densities of dopamine D

Indexed as

Cocaine-Related DisordersConnectomeMagnetic Resonance ImagingReceptors, Dopamine D2Receptors, Dopamine D3AdultBrainFemaleHumansMaleMiddle AgedPositron-Emission TomographyDRD2 protein, humanDRD3 protein, humanReceptors, Dopamine D2Receptors, Dopamine D3

Identifiers

PMID39300138
PMCPMC11413242

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.