Evidence map›Paper›PMID 39300119›Full record

ArticleScientific reports2024

Association of periodontitis with all-cause and cause-specific mortality among individuals with depression: a population-based study.

Yonghuan Zhang, Shanfeng Lin, Xuzhuo Chen, Hongbing Lan, Weiqi Li, Li Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yonghuan ZhangDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning, People's Republic of China.
Shanfeng LinDepartment of Oroamxillofacial-Head and Neck Surgery, School of Stomatology, China Medical University, Shenyang, Liaoning, People's Republic of China.
Xuzhuo ChenShanghai Key Laboratory of Stomatology, Department of Oral Surgery, Shanghai Ninth People's Hospital, National Clinical Research Center for Oral Diseases, National Center for Stomatology, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Hongbing LanApplied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong kong, China.
Weiqi LiState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, Sichuan University, Chengdu, Sichuan, People's Republic of China. liweiqi@stu.scu.edu.cn.
Li LinDepartment of Periodontology, School of Stomatology, China Medical University, Shenyang, Liaoning, People's Republic of China. linli@cmu.edu.cn.

Funding

Liaoning Provincial Applied Basic Research Program Project 2023JH2/101300042National Natural Science Foundation of China 81970942
6 · The paper itself

Abstract

To detect the association between periodontitis and all-cause as well as cause-specific mortality rates among adults diagnosed with depression. Participants diagnosed with depression were selected from NHANES across three periods (1988-1994; 1999-2004; 2009-2014). Cox proportional hazards and Weibull accelerated failure time (AFT) models were utilized to calculate hazard ratios (HRs), time ratios (TRs), and their 95% confidence intervals (CIs) to evaluate the association between moderate-to-severe periodontitis and all-cause as well as cause-specific mortality among participants with depression. white blood counts and C-reactive protein were used to assess the mediating role of systemic inflammation. Among the 1,189 participants with a median follow-up of 9.25 years, 133 deaths were recorded. After adjusting for multiple variables, moderate-to-severe periodontitis was obvious associated with an increased risk of cancer-related mortality in individuals with depression (Cox: HR 3.22, 95% CI 1.51-6.83, P = 0.002; AFT: TR 0.70, 95% CI 0.52-0.94, P = 0.017). Neither WBC nor CRP significantly mediate the association between periodontitis and cancer-related mortality. The risk of cancer-related mortality rose with the severity of periodontitis (P for trend = 0.021). However, no association was observed between moderate-to-severe periodontitis and other kinds of mortality. Moderate-to-severe periodontitis is linked to an elevated risk of cancer-related mortality among adults diagnosed with depression, with the mortality risk increasing alongside the severity of periodontitis. No significant mediating effect of systemic inflammation was found in this association. These findings highlight the importance of addressing periodontal health in individuals with depression. By uncovering the association between periodontitis and mortality in this population, our study underscores the potential benefits of preventive dental care and periodontal treatment in reducing the risk of cancer-related mortality in individuals with depression.

Indexed as

DepressionPeriodontitisAdultAgedCause of DeathC-Reactive ProteinFemaleHumansMaleMiddle AgedNeoplasmsNutrition SurveysProportional Hazards ModelsRisk FactorsC-Reactive Protein

Identifiers

PMID39300119
PMCPMC11413212

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