Evidence map›Paper›PMID 39300109›Full record

ArticleNature communications2024

Immune profiling-based targeting of pathogenic T cells with ustekinumab in ANCA-associated glomerulonephritis.

Jonas Engesser, Robin Khatri, Darius P Schaub, Yu Zhao, Hans-Joachim Paust, Zeba Sultana, Nariaki Asada, Jan-Hendrik Riedel, Varshi Sivayoganathan, Anett Peters and 14 more

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Jonas Engesser *Department of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Robin Khatri *Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0009-0006-5311-1718
Darius P Schaub *Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Yu ZhaoDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-2632-7530
Hans-Joachim PaustDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Zeba SultanaDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-6610-9955
Nariaki AsadaDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jan-Hendrik RiedelDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Varshi SivayoganathanDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anett PetersDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Anna KaffkeDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Saskia-Larissa Jauch-SpeerDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-6739-3051
Thiago Goldbeck-StriederDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Victor G PuellesDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Ulrich O WenzelDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-0116-255X
Oliver M SteinmetzDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-5142-328X
Elion HoxhaDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jan-Eric TurnerDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0002-1677-5455
Hans-Willi MittrückerHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-6166-4191
Thorsten WiechHamburg Center for Kidney Health (HCKH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0003-4053-1474
Tobias B HuberDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID 0000-0001-7175-5062
Stefan BonnHamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. s.bonn@uke.de.
Christian F KrebsDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. c.krebs@uke.de.ORCID 0000-0003-2739-5578
Ulf PanzerDepartment of Medicine III, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. panzer@uke.de.ORCID 0000-0001-9449-0722

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1192
6 · The paper itself

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis is a life-threatening autoimmune disease that often results in kidney failure caused by crescentic glomerulonephritis (GN). To date, treatment of most patients with ANCA-GN relies on non-specific immunosuppressive agents, which may have serious adverse effects and be only partially effective. Here, using spatial and single-cell transcriptome analysis, we characterize inflammatory niches in kidney samples from 34 patients with ANCA-GN and identify proinflammatory, cytokine-producing CD4

Indexed as

Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisGlomerulonephritisUstekinumabAdultAgedAntibodies, Antineutrophil CytoplasmicCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCyclophosphamideFemaleGene Expression ProfilingHumansImmunosuppressive AgentsInterleukin-12KidneyMaleAntibodies, Antineutrophil CytoplasmicCyclophosphamideImmunosuppressive AgentsInterleukin-12Ustekinumab

Identifiers

PMID39300109
PMCPMC11413367

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.