Evidence map›Paper›PMID 39300011›Full record

ReviewAmerican journal of clinical dermatology2024

Chronic Hand Eczema.

Elke Weisshaar

Registry-linked trialAbstract readReview
In one paragraph

Review in American journal of clinical dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07286487 (Effects of Glycyrrhetinic Acid on Human Skin in an Acute Irritant Contact Dermatitis Model), which is not on this map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07286487 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Glycyrrhetinic Acid on Human Skin in an Acute Irritant Contact Dermatitis Model

TypeinterventionalSponsorUniversity of Split, School of MedicineRan2026 to 2027Enrolled30ConditionsIrritant Contact DermatitisArmsSLS induced irritation, No Treatment, Placebo, Lower Dose Glycyrrhetinic Acid, Higher Dose Glycyrrhetinic Acid
3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. [New diagnostic possibilities in hand eczema].Dermatologie (Heidelberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Consensus on core domains for hand eczema trials: Signs, symptoms, control and quality of life.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Article
  17. A Practical Approach to Chronic Hand Eczema.Dermatology and therapy · 2025
    Article
  18. Chronic Hand Eczema (CHE): A Narrative Review.Dermatology and therapy · 2025
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Elke WeisshaarDivision of Occupational Dermatology, Department of Dermatology, University Hospital Heidelberg, Ruprecht Karls University Heidelberg, Voßstr. 2, 69115, Heidelberg, Germany. elke.weisshaar@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0002-7016-0224

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hand eczema (CHE) is a complex, challenging, and frequently multifactorial skin disease of the hands. It is very common in the general population, especially in certain professions. When hand eczema (HE) persists for longer than 3 months or has a minimum of two relapses per year after initial manifestation with complete clearance, it is considered chronic. In this case, health-related quality of life and the patient's working life are often impaired. CHE can be considered as an umbrella term because it covers different clinical pictures and etiologies. To date, there is no definite and unique HE classification. Treatment starts with identifying the individual HE etiology paralleled by symptomatic therapy (local and/or systemic and/or ultraviolet phototherapy). Sustainable management of HE requires the identification and avoidance of its triggering factors, from the professional and private environment. This includes ruling out allergic contact dermatitis if any HE persists for more than 3 months despite adequate therapy. Randomized controlled trials investigating the efficacy in HE are lacking for several treatment modalities. Patient education measures of skin protection and prevention complete the multimodal treatment.

Indexed as

EczemaHand DermatosesQuality of LifeChronic DiseaseDermatitis, OccupationalHumansPatient Education as TopicUltraviolet Therapy

Identifiers

PMID39300011
PMCPMC11511713

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.