Evidence map›Paper›PMID 39300008›Full record

Trial reportCanadian journal of anaesthesia = Journal canadien d'anesthesie2024

Maintenance infusion rate of oxytocin after initial 1-IU bolus for elective Cesarean delivery: a dose-finding study.

Linda Boonstra, Jose C A Carvalho, William Turner, Kristi Downey, Xiang Y Ye, Jackie Thomas, Mrinalini Balki

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04946006 (Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04946006 nacompletednot on this map

Maintenance Infusion of Oxytocin Following Elective Cesarean Deliveries: an Up-down Sequential Allocation Dose-response Study

TypeinterventionalSponsorSamuel Lunenfeld Research Institute, Mount Sinai HospitalRan2021 to 2022Enrolled40ConditionsPostpartum HemorrhageArmsOxytocin
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Oxytocin protocols during Cesarean delivery: optimizing the tone zone.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda BoonstraDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Jose C A CarvalhoDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
William TurnerDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Kristi DowneyDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Xiang Y YeDepartment of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Jackie ThomasDepartment of Obstetrics and Gynecology Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Mrinalini BalkiDepartment of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. mrinalini.balki@uhn.ca.ORCID 0000-0001-6568-021X

Funding

Non-US Government Research Support
6 · The paper itself

Abstract

purposeThe purpose of our study was to determine the minimum effective dose of oxytocin maintenance infusion required to maintain adequate uterine tone in 90% of patients (ED

methodsWe conducted a prospective, double-blind dose-finding study with biased coin up-down design. Immediately after delivery, a 1-IU oxytocin bolus was administered, followed by a maintenance infusion. The obstetrician assessed the uterine tone by palpation as satisfactory or unsatisfactory. In case of unsatisfactory response, the dose for the next patient was increased by 2 IU·hr

resultsWe analyzed data for 40 patients. The ED

conclusionBased on the results of this dose-finding study, we recommend a maintenance infusion rate of 4.5 IU·hr STUDY REGISTRATION: ClinicalTrials.gov ( NCT04946006 ); first submitted 25 June 2021.

Indexed as

Anesthesia, SpinalCesarean SectionDose-Response Relationship, DrugOxytocicsOxytocinAdultDouble-Blind MethodElective Surgical ProceduresFemaleHumansInfusions, IntravenousPregnancyProspective StudiesOxytocicsOxytocinCesarean deliverymaintenance infusionoxytocin

Identifiers

PMID39300008

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.