Evidence map›Paper›PMID 39299782›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2024

Validation of a Simplified Tissue-to-Reference Ratio Measurement Using SUVR to Assess Synaptic Density Alterations in Alzheimer Disease with [

Juan J Young, Ryan S O'Dell, Mika Naganawa, Takuya Toyonaga, Ming-Kai Chen, Nabeel B Nabulsi, Yiyun Huang, Emma Cooper, Alyssa Miller, Jessica Lam and 7 more

Abstract readValidation Study
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Assessment of noninvasive quantification of [European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Article
  4. Article
  5. Imaging Synaptic Density in Aging and Alzheimer Disease with [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  6. Frontiers in medicine · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Juan J YoungAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Ryan S O'DellAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Mika NaganawaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Ming-Kai ChenDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Nabeel B NabulsiDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Emma CooperAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Alyssa MillerAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Jessica LamAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Kara BatesAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Audrey RuanAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Kimberly NelsenAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Elaheh SalardiniAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.
Christopher H van DyckAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut.
Adam P MeccaAlzheimer's Disease Research Unit, Yale School of Medicine, New Haven, Connecticut; adam.mecca@yale.edu.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PET Imaging of SV2A and Other Biomarkers in Alzheimer's DiseaseR01AG062276 · NIA · YALE UNIVERSITY · PI VAN DYCK, CHRISTOPHER H · 2018 to 2022
$5.5M
PET Imaging of Synaptic Density in Alzheimers DiseaseR01AG052560 · NIA · YALE UNIVERSITY · PI CARSON, RICHARD E., VAN DYCK, CHRISTOPHER H · 2017 to 2020
$3.2M
Investigation of molecular changes in mGluR5 and SV2A to study synaptic alterations in Alzheimer's disease using PET.K23AG057794 · NIA · YALE UNIVERSITY · PI MECCA, ADAM PETER · 2018 to 2022
$977k
PUBLIC HEALTH AND AGING TRAINING PROGRAMT32AG000134 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WEISSERT, WILLIAM G · 1986 to 2002
$30k
NCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA006973NIA NIH HHS K23 AG057794NIA NIH HHS R01 AG052560NIA NIH HHS R01 AG062276NIA NIH HHS T32 AG000134
6 · The paper itself

Abstract

Simplified methods of acquisition and quantification would facilitate the use of synaptic density imaging in multicenter and longitudinal studies of Alzheimer disease (AD). We validated a simplified tissue-to-reference ratio method using SUV ratios (SUVRs) for estimating synaptic density with [

Indexed as

Alzheimer DiseasePositron-Emission TomographySynapsesAgedAged, 80 and overFemaleHumansMalePyridinesPyrrolidinonesRadiopharmaceuticals1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-onePyridinesPyrrolidinonesRadiopharmaceuticals[11C]UCB-JAlzheimer diseasePETSUVRsynaptic density

Identifiers

PMID39299782
PMCPMC11533916

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.