Evidence map›Paper›PMID 39299780›Full record

ArticleJournal of psychiatry & neuroscience : JPN

Interaction of the gut microbiota and brain functional connectivity in late-life depression.

Chia-Fen Tsai, Chia-Hsien Chuang, Pei-Chi Tu, Wan-Chen Chang, Yen-Po Wang, Pei-Yi Liu, Po-Shan Wu, Chung-Yen Lin, Ching-Liang Lu

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Article in Journal of psychiatry & neuroscience : JPN. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chia-Fen TsaiFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Chia-Hsien ChuangFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Pei-Chi TuFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Wan-Chen ChangFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Yen-Po WangFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Pei-Yi LiuFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Po-Shan WuFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Chung-Yen LinFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan.
Ching-Liang LuFrom the Institute of Brain Science (Wang, Liu, Wu, Lu), Faculty of Medicine (Tsai, Wang, Lu), Institute of Philosophy of Mind and Cognition (Tu), Department of Biomedical Engineering (Chang), the National Yang Ming Chiao Tung University, Taipei, Taiwan; the Endoscopy Center for Diagnosis and Treatment (Wang, Liu, Lu), Department of Medicine (Wang, Lu), Division of Gastroenterology, Department of Psychiatry (Tu, Chang), Department of Medical Research (Tu, Chang), Department of Dietetics & Nutrition (Wu), Taipei Veterans General Hospital, Taipei, Taiwan; the Institute of Information Science (Chuang, Lin), Academia Sinica, Taiwan; Yours Clinic (Tsai), Taipei, Taiwan cllu@ym.edu.tw cllu@vghtpe.gov.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIncreasing evidence suggests an important role of the gut microbiome in the pathogenesis of mental disorders, including depression, along the microbiota-gut-brain axis. We sought to explore the interactions between gut microbe composition and neural circuits in late-life depression (LLD).

methodsWe performed fecal 16S ribosomal RNA (rRNA) sequencing and resting-state functional magnetic resonance imaging in a case-control cohort of older adults with LLD and healthy controls to characterize the association between gut microbiota and brain functional connectivity (FC). We used the Hamilton Depression Rating Scale (HAMD) to assess depressive symptoms.

resultsWe included 32 adults with LLD and 16 healthy controls. At the genus level, the relative abundance of LIMITATIONS: The study's cross-sectional design and small sample size limit causal inferences; larger longitudinal studies are required for detailed subgroup analyses.

conclusionWe identified significant correlations between LDD-characterized gut microbes and brain FC, as well as depression severity, which may contribute to the pathophysiology of depression development among patients with LLD. Specific microbes were linked to altered brain connectivity, suggesting potential targets for treating LLD.

Indexed as

Gastrointestinal MicrobiomeMagnetic Resonance ImagingAgedBrainBrain-Gut AxisCase-Control StudiesFecesFemaleHumansMajor Depressive DisorderMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16S

Identifiers

PMID39299780
PMCPMC11426387

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.