Evidence map›Paper›PMID 39299709›Full record

ArticleVox sanguinis2024

Regular whole blood donation and gastrointestinal, breast, colorectal and haematological cancer risk among blood donors in Australia.

Md Morshadur Rahman, Andrew Hayen, John K Olynyk, Anne E Cust, David O Irving, Surendra Karki

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In one paragraph

Article in Vox sanguinis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Md Morshadur RahmanSchool of Public Health, University of Technology Sydney, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0002-6610-4043
Andrew HayenSchool of Public Health, University of Technology Sydney, Sydney, New South Wales, Australia.
John K OlynykCurtin Medical School, Curtin University, Bentley, Western Australia, Australia.
Anne E CustThe Daffodil Centre, The University of Sydney, a joint venture with Cancer Council NSW, Sydney, New South Wales, Australia.
David O IrvingSchool of Public Health, University of Technology Sydney, Sydney, New South Wales, Australia.
Surendra KarkiResearch and Development, Australian Red Cross Lifeblood, Sydney, New South Wales, Australia.ORCID https://orcid.org/0000-0003-1561-4171

Funding

Australian governments fund Australian Red Cross Lifeblood to provide blood, blood products and services to the Australian communityUniversity of New South Wales
6 · The paper itself

Abstract

BACKGROUND AND

objectivesSeveral studies have suggested that blood donors have lower risk of gastrointestinal and breast cancers, whereas some have indicated an increased risk of haematological cancers. We examined these associations by appropriately adjusting the 'healthy donor effect' (HDE). MATERIALS AND

methodsWe examined the risk of gastrointestinal/colorectal, breast and haematological cancers in regular high-frequency whole blood (WB) donors using the Sax Institute's 45 and Up Study data linked with blood donation and other health-related data. We calculated 5-year cancer risks, risk differences and risk ratios. To mitigate HDE, we used 5-year qualification period to select the exposure groups, and applied statistical adjustments using inverse probability weighting, along with other advanced doubly robust g-methods.

resultsWe identified 2867 (42.4%) as regular high-frequency and 3888 (57.6%) as low-frequency donors. The inverse probability weighted 5-year risk difference between high and low-frequency donors for gastrointestinal/colorectal cancer was 0.2% (95% CI, -0.1% to 0.5%) with a risk ratio of 1.25 (0.83-1.68). For breast cancer, the risk difference was -0.2% (-0.9% to 0.4%), with a risk ratio of 0.87 (0.48-1.26). Regarding haematological cancers, the risk difference was 0.0% (-0.3% to 0.5%) with a risk ratio of 0.97 (0.55-1.40). Our doubly robust estimators targeted minimum loss-based estimator (TMLE) and sequentially doubly robust (SDR) estimator, yielded similar results, but none of the findings were statistically significant.

conclusionAfter applying methods to mitigate the HDE, we did not find any statistically significant differences in the risk of gastrointestinal/colorectal, breast and haematological cancers between regular high-frequency and low-frequency WB donors.

Indexed as

Blood DonorsBreast NeoplasmsColorectal NeoplasmsHematologic NeoplasmsAdultAgedAustraliaBlood DonationFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedRisk Factorsblood donorcancerHDEhealthy donor effectmalignancywhole blood

Identifiers

PMID39299709
PMCPMC11634440

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.