Evidence map›Paper›PMID 39299611›Full record

ArticleJournal of thrombosis and haemostasis : JTH2025

Alterations in visible light exposure modulate platelet function and regulate thrombus formation.

Elizabeth A Andraska, Frederik Denorme, Christof Kaltenmeier, Aishwarrya Arivudainabi, Emily P Mihalko, Mitchell Dyer, Gowtham K Annarapu, Mohammadreza Zarisfi, Patricia Loughran, Mehves Ozel and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Circadian clock regulation of hemostasis: a systematic review of molecular pathways.Research and practice in thrombosis and haemostasis · 2026
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Elizabeth A AndraskaDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA. Electronic address: andraskaea@upmc.edu.
Frederik DenormeDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Christof KaltenmeierUniversity of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA; MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC, USA.
Aishwarrya ArivudainabiUniversity of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA.
Emily P MihalkoDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mitchell DyerDivision of Vascular and Endovascular Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Gowtham K AnnarapuPittsburgh Heart, Lung, Blood, Vascular Medicine Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Mohammadreza ZarisfiDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Patricia LoughranDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA.
Mehves OzelDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kelly WilliamsonDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Roberto Ivan Mota AlvidrezCollege of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA.
Kimberly ThomasVitalant Research Institute, Denver, Colorado, USA; Department of Pathology, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.
Sruti ShivaDivision of Classical Hematology, Department of Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Susan M SheaDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Richard A SteinmanUniversity of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA; Division of Hematology and Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Robert A CampbellDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Matthew R RosengartDivision of Acute and Critical Care Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Matthew D NealDepartment of Surgery, Trauma and Transfusion Medicine Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; University of Pittsburgh Medical School, Pittsburgh, Pennsylvania, USA.

Funding

Proteomics CoreU54DK110858 · NIDDK · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Anna E Beaudin, JAMES Eric COX · 2016 to 2026
$8.6M
Vascular Surgery Research Training (VascTrain) ProgramT32HL098036 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Edith Tzeng · 2010 to 2026
$7.2M
Mechanistic Elucidation and Targeted Therapy of Platelet Dysfunction After TraumaR35GM119526 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEAL, MATTHEW D · 2016 to 2025
$3.9M
Calcium homeostasis and cellular fitness in sepsisR01GM147121 · NIGMS · WASHINGTON UNIVERSITY · PI ROSENGART, MATTHEW RANDALL · 2022 to 2025
$2.3M
Platelet-Mediated Neutrophil Extracellular Traps Regulate Ischemic Stroke InjuryR01HL163019 · NHLBI · WASHINGTON UNIVERSITY · PI CAMPBELL, ROBERT A · 2022 to 2025
$2.2M
HUMAN PLATELET PAR4: NOVEL ACTIVATION, INTERINDIVIDUAL VARIATION, AND NEUTROPHIL INTERACTIONS IN VIVO AND IN VITROR01HL160808 · NHLBI · WASHINGTON UNIVERSITY · PI CAMPBELL, ROBERT A · 2022 to 2025
$2.1M
The role of circadian clock proteins in innate and adaptive immunityR01GM145674 · NIGMS · WASHINGTON UNIVERSITY · PI ROSENGART, MATTHEW RANDALL · 2022 to 2025
$1.5M
Blue light protects against ischemia induced organ injuryR01GM116929 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSENGART, MATTHEW RANDALL · 2016 to 2019
$1.2M
Agilent 6550 QTOF system for U of UtahS10OD016232 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2013 to 2013
$578k
High-Throughput Computing for Genomics and Bioinformatics ResearchS10OD028483 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEE, ADRIAN V · 2021 to 2021
$574k
Q-ToF Mass Spectrometer for the University of Utah MS and Proteomics CoreS10OD018210 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2015 to 2015
$530k
Agilent 7200 GC/Q-TOF for the University of UtahS10OD021505 · OD · UNIVERSITY OF UTAH · PI COX, JAMES ERIC · 2016 to 2016
$401k
NHLBI NIH HHS R01 HL160808NHLBI NIH HHS R01 HL163019NHLBI NIH HHS T32 HL098036NIA NIH HHS K01 AG059892NIDDK NIH HHS U54 DK110858NIGMS NIH HHS R01 GM116929NIGMS NIH HHS R01 GM145674NIGMS NIH HHS R01 GM147121NIGMS NIH HHS R35 GM119526NIH HHS S10 OD016232NIH HHS S10 OD018210NIH HHS S10 OD019973NIH HHS S10 OD021505NIH HHS S10 OD028483
6 · The paper itself

Abstract

backgroundVariations in light exposure are associated with changes in inflammation and coagulation. The impact of light spectra on venous thrombosis (VT) and arterial thrombosis is largely unexplored.

objectivesTo investigate the impact of altering light spectrum on platelet function in thrombosis.

methodsWild-type C57BL/6J mice were exposed to ambient (mice

resultsExposure to long-wavelength red light resulted in reduced platelet aggregation and activation. RNA-seq analysis demonstrated no significant transcriptomic changes between mice

conclusionLight therapy may be a promising approach to thrombus prophylaxis by specifically targeting the intersection between innate immune function and coagulation.

Indexed as

Blood CoagulationBlood PlateletsLightPlatelet AggregationThrombosisVenous ThromboembolismVenous ThrombosisAgedAnimalsDisease Models, AnimalExtracellular TrapsFemaleHumansMaleMetabolomicsMiceembolism and thrombosisplatelet activationplatelet aggregationvenous thrombosis

Identifiers

PMID39299611
PMCPMC12066021

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.