Evidence map›Paper›PMID 39298668›Full record

ArticleJournal of agricultural and food chemistry2024

Quantitative NMR Analysis of Marine Macroalgae for AGE Inhibition by Methylglyoxal Scavenging.

George S Hanna, Victoria J Findlay, David P Turner, Mark T Hamann

Abstract readEvaluation Study
In one paragraph

Article in Journal of agricultural and food chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

George S HannaDepartment of Biomedical Sciences and Drug Discovery, Medical University of South Carolina, Charleston, South Carolina 29425, United States.ORCID 0000-0001-7616-064X
Victoria J FindlayDepartment of Surgery, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
David P TurnerDepartment of Surgery, Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, Virginia 23298, United States.
Mark T HamannDepartment of Biomedical Sciences and Drug Discovery, Medical University of South Carolina, Charleston, South Carolina 29425, United States.ORCID 0000-0002-3798-4002

Funding

Synthesis and Optimization of the Aleutianamine Class of AlkaloidsR01GM145845 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HAMANN, MARK T, TIUS, MARCUS ANTONIUS · 2022 to 2025
$2.4M
Lifestyle associated reactive metabolites and their negative impact on breast cancer riskR01CA245143 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI FINDLAY, VICTORIA JANE, TURNER, DAVID PAUL · 2020 to 2024
$2.1M
Cause and Effect Relationships Between Glycation and the Ancestry Specific Tumor StromaR01CA259415 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI David Paul Turner · 2023 to 2026
$1.7M
Complimentary NMR and Bio-Assay Guided Screening of Edible Marine Algae for AGE Inhibitors to Control Glycative Stress and Reduce Risk of Neurodegeneration.F31AT011158 · NCCIH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI HANNA, GEORGE STEVEN · 2020 to 2022
$132k
NCCIH NIH HHS F31 AT011158NCI NIH HHS R01 CA245143NCI NIH HHS R01 CA259415NIGMS NIH HHS R01 GM145845
6 · The paper itself

Abstract

Reactive carbonyl species (RCS) induce a fundamental form of biological stress that has driven the evolution of diverse mechanisms for minimizing its impact on organismal health. The complications that accompany uncontrolled hyperglycemia exemplify the health implications when RCS stress exceeds the body's capacity to prevent the excessive formation of advanced glycation end-products. Presented here is a novel quantitative NMR (qNMR) technique for evaluating scavengers of the prominent sugar-derived carbonyl methylglyoxal (MGO). This tool was employed to screen the chemical diversity of marine macroalgae extracts, with a focus on species that have a history of consumption by the World's healthiest populations and are subject to global scale aquacultural production.

Indexed as

Glycation End Products, AdvancedMagnetic Resonance SpectroscopyPyruvaldehydeSeaweedGracilariaHumansPlant ExtractsGlycation End Products, AdvancedPlant ExtractsPyruvaldehydeadvanced glycation end productsAGEsglycationmethylglyoxalqNMR

Identifiers

PMID39298668
PMCPMC11653393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.