Evidence map›Paper›PMID 39298664›Full record

ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2024

Novel systematic processing of cardiac magnetic resonance imaging identifies target regions associated with infarct-related ventricular tachycardia.

Alba Ramos-Prada, Andrés Redondo-Rodríguez, Ivo Roca-Luque, Andreu Porta-Sánchez, Rachel M A Ter Bekke, Jorge G Quintanilla, Javier Sánchez-González, Rafael Peinado, Jose Luis Merino, Matthijs Cluitmans and 15 more

Abstract readMulticenter StudyValidation Study
In one paragraph

Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Catheter ablation vs. anti-arrhythmic drug therapy for ventricular tachycardia in ischaemic heart disease: a meta-analysis of randomized controlled trials.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Pooled it
  2. Imaging phenotypes and substrates in ventricular tachycardia.Herzschrittmachertherapie & Elektrophysiologie · 2026
    Review
  3. Review
  4. Article
  5. Outcomes of ventricular tachycardia ablation facilitated by pre-procedural cardiac imaging-derived scar characterization: a prospective multi-centre international registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  6. Epicardial ventricular arrhythmia ablation: a clinical consensus statement of the European Heart Rhythm Association of the European Society of Cardiology and the Heart Rhythm Society, the Asian Pacific Heart Rhythm Society, the Latin American Heart Rhythm Society, and the Canadian Heart Rhythm Society.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Alba Ramos-PradaNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0001-6387-3325
Andrés Redondo-RodríguezNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0001-7018-0711
Ivo Roca-LuqueCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029, Madrid, Spain.ORCID 0000-0003-0731-3731
Andreu Porta-SánchezCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029, Madrid, Spain.ORCID 0000-0003-3510-1488
Rachel M A Ter BekkeDepartment of Cardiology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands.ORCID 0000-0003-4278-0132
Jorge G QuintanillaNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0002-2227-3507
Javier Sánchez-GonzálezPhilips Healthcare Iberia, Madrid, Spain.ORCID 0000-0003-1427-3870
Rafael PeinadoCardiology Department, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0002-3686-0892
Jose Luis MerinoCardiology Department, Hospital Universitario La Paz, Madrid, Spain.ORCID 0000-0002-1737-1903
Matthijs CluitmansCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0002-3456-7668
Robert J HoltackersCardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0003-1809-313X
Manuel Marina-BreysseNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0002-2047-1868
Carlos Galán-ArriolaNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0001-7403-8974
Daniel Enríquez-VázquezCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029, Madrid, Spain.
Sara Vázquez-CalvoDepartment of Cardiology, Hospital Clínic, Barcelona, Spain.
José Manuel Alfonso-AlmazánNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0003-1233-9135
Gonzalo PizarroNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0002-5082-3596
Borja IbáñezNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0002-5036-254X
Juan José González-FerrerCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029, Madrid, Spain.
Ricardo Salgado-ArandaInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain.ORCID 0000-0002-2627-8436
Victoria Cañadas-GodoyCentro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Avenida Monforte de Lemos, 3-5, Pabellón 11, Planta 0, 28029, Madrid, Spain.ORCID 0000-0003-2312-8288
David CalvoInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Cardiovascular Institute, Madrid, Spain.ORCID 0000-0002-8689-4011
Julián Pérez-VillacastínFundación Interhospitalaria para la Investigación Cardiovascular (FIC), Madrid, Spain.
Nicasio Pérez-CastellanoFundación Interhospitalaria para la Investigación Cardiovascular (FIC), Madrid, Spain.ORCID 0000-0003-0359-939X
David Filgueiras-RamaNovel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, 28029, Madrid, Spain.ORCID 0000-0001-5909-2454

Funding

Centro Nacional de Investigaciones CardiovascularesFondo Europeo de Desarrollo Regional CB16/11/00458Fundación Eugenio Rodríguez PascualFundación Interhospitalaria para la Investigación CardiovascularHeart Rhythm Association of the Spanish Society of CardiologyMinistry of Science and InnovationPro CNIC Foundation CEX2020-001041-S
6 · The paper itself

Abstract

aimsThere is lack of agreement on late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) imaging processing for guiding ventricular tachycardia (VT) ablation. We aim at developing and validating a systematic processing approach on LGE-CMR images to identify VT corridors that contain critical VT isthmus sites. METHODS AND

resultsThis is a translational study including 18 pigs with established myocardial infarction and inducible VT undergoing in vivo characterization of the anatomical and functional myocardial substrate associated with VT maintenance. Clinical validation was conducted in a multicentre series of 33 patients with ischaemic cardiomyopathy undergoing VT ablation. Three-dimensional LGE-CMR images were processed using systematic scanning of 15 signal intensity (SI) cut-off ranges to obtain surface visualization of all potential VT corridors. Analysis and comparisons of imaging and electrophysiological data were performed in individuals with full electrophysiological characterization of the isthmus sites of at least one VT morphology. In both the experimental pig model and patients undergoing VT ablation, all the electrophysiologically defined isthmus sites (n = 11 and n = 19, respectively) showed overlapping regions with CMR-based potential VT corridors. Such imaging-based VT corridors were less specific than electrophysiologically guided ablation lesions at critical isthmus sites. However, an optimized strategy using the 7 most relevant SI cut-off ranges among patients showed an increase in specificity compared to using 15 SI cut-off ranges (70 vs. 62%, respectively), without diminishing the capability to detect VT isthmus sites (sensitivity 100%).

conclusionSystematic imaging processing of LGE-CMR sequences using several SI cut-off ranges may improve and standardize procedure planning to identify VT isthmus sites.

Indexed as

Catheter AblationDisease Models, AnimalMyocardial InfarctionTachycardia, VentricularAgedAnimalsContrast MediaElectrophysiologic Techniques, CardiacFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsContrast MediaImaging processingMagnetic resonance imagingRadiofrequency ablationVentricular tachycardia

Identifiers

PMID39298664
PMCPMC11472157

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.